IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v468y2010i7325d10.1038_nature09557.html
   My bibliography  Save this article

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

Author

Listed:
  • Lucia Ricci-Vitiani

    (Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299)

  • Roberto Pallini

    (Catholic University of Rome, Largo Francesco Vito 1)

  • Mauro Biffoni

    (Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299)

  • Matilde Todaro

    (University of Palermo, Via Liborio Giuffrè 5)

  • Gloria Invernici

    (U. O. Cerebrovascular Disease Cellular Neurobiology Laboratory, Fondazione IRCCS, Neurological Institute “Carlo Besta”, Via Celoria 11)

  • Tonia Cenci

    (Institute of Pathology, Catholic University of Rome, Largo Francesco Vito 1)

  • Giulio Maira

    (Catholic University of Rome, Largo Francesco Vito 1)

  • Eugenio Agostino Parati

    (U. O. Cerebrovascular Disease Cellular Neurobiology Laboratory, Fondazione IRCCS, Neurological Institute “Carlo Besta”, Via Celoria 11)

  • Giorgio Stassi

    (University of Palermo, Via Liborio Giuffrè 5
    Cellular and Molecular Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Salvatore Maugeri, Via S. Maugeri 6)

  • Luigi Maria Larocca

    (Institute of Pathology, Catholic University of Rome, Largo Francesco Vito 1)

  • Ruggero De Maria

    (Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299
    Mediterranean Institute of Oncology, Via Penninazzo 7, 95029, Viagrande, Catania, Italy)

Abstract

Tumour cells that supply their own blood Glioblastomas are aggressive brain cancers that are nourished by an extensive network of blood vessels. Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells and seem to be derived from glioblastoma stem-like cells. This work suggests that some putative cancer stem cells promote cancer growth both directly and indirectly, and may explain the failure of certain anti-angiogenic cancer drugs and aid the design of new therapies.

Suggested Citation

  • Lucia Ricci-Vitiani & Roberto Pallini & Mauro Biffoni & Matilde Todaro & Gloria Invernici & Tonia Cenci & Giulio Maira & Eugenio Agostino Parati & Giorgio Stassi & Luigi Maria Larocca & Ruggero De Mar, 2010. "Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells," Nature, Nature, vol. 468(7325), pages 824-828, December.
  • Handle: RePEc:nat:nature:v:468:y:2010:i:7325:d:10.1038_nature09557
    DOI: 10.1038/nature09557
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09557
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature09557?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Guiraldello, Rafael T. & Martins, Marcelo L. & Mancera, Paulo F.A., 2016. "Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 456(C), pages 145-156.
    2. Lata Adnani & Jordan Kassouf & Brian Meehan & Cristiana Spinelli & Nadim Tawil & Ichiro Nakano & Janusz Rak, 2022. "Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Sree Deepthi Muthukrishnan & Riki Kawaguchi & Pooja Nair & Rachna Prasad & Yue Qin & Maverick Johnson & Qing Wang & Nathan VanderVeer-Harris & Amy Pham & Alvaro G. Alvarado & Michael C. Condro & Fuyin, 2022. "P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Eunnyung Bae & Ping Huang & Gaёlle Müller-Greven & Dolores Hambardzumyan & Andrew Edward Sloan & Amy S. Nowacki & Nicholas Marko & Cathleen R. Carlin & Candece L. Gladson, 2022. "Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Ting Xie & Adi Danieli-Mackay & Mariachiara Buccarelli & Mariano Barbieri & Ioanna Papadionysiou & Q. Giorgio D’Alessandris & Claudia Robens & Nadine Übelmesser & Omkar Suhas Vinchure & Liverana Laure, 2024. "Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:468:y:2010:i:7325:d:10.1038_nature09557. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.