IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v468y2010i7324d10.1038_nature09595.html
   My bibliography  Save this article

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

Author

Listed:
  • Boyi Gan

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Jian Hu

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Shan Jiang

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Yingchun Liu

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Ergün Sahin

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Li Zhuang

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Eliot Fletcher-Sananikone

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Simona Colla

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Y. Alan Wang

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Lynda Chin

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Ronald A. DePinho

    (Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

Abstract

Lkb1 promotes haematopoietic stem cell survival Haematopoietic stem cells are very sensitive to energetic and oxidative stress, and modulation of the balance between their quiescence and proliferation is needed to respond to metabolic stress while preserving their long-term regenerative capacity. Three new studies show that the tumour suppressor and metabolic sensor Lkb1 has a crucial role in maintaining energy homeostasis in haematopoietic cells. Lkb1 is shown to be necessary for cell-cycle regulation as well as for energy homeostasis, and haematopoietic stem cells depend more acutely on Lkb1 than any other haematopoietic cells.

Suggested Citation

  • Boyi Gan & Jian Hu & Shan Jiang & Yingchun Liu & Ergün Sahin & Li Zhuang & Eliot Fletcher-Sananikone & Simona Colla & Y. Alan Wang & Lynda Chin & Ronald A. DePinho, 2010. "Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells," Nature, Nature, vol. 468(7324), pages 701-704, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7324:d:10.1038_nature09595
    DOI: 10.1038/nature09595
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09595
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09595?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Qiang Zhao & Young-Min Han & Ping Song & Zhixue Liu & Zuyi Yuan & Ming-Hui Zou, 2022. "Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Yuelong Yan & Hongqi Teng & Qinglei Hang & Lavanya Kondiparthi & Guang Lei & Amber Horbath & Xiaoguang Liu & Chao Mao & Shiqi Wu & Li Zhuang & M. James You & Masha V. Poyurovsky & Li Ma & Kellen Olsze, 2023. "SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:468:y:2010:i:7324:d:10.1038_nature09595. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.