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Sugar transporters for intercellular exchange and nutrition of pathogens

Author

Listed:
  • Li-Qing Chen

    (Carnegie Institution for Science)

  • Bi-Huei Hou

    (Carnegie Institution for Science)

  • Sylvie Lalonde

    (Carnegie Institution for Science)

  • Hitomi Takanaga

    (Carnegie Institution for Science)

  • Mara L. Hartung

    (Carnegie Institution for Science)

  • Xiao-Qing Qu

    (Carnegie Institution for Science)

  • Woei-Jiun Guo

    (Carnegie Institution for Science)

  • Jung-Gun Kim

    (Stanford University, 228A Gilbert Bioscience Building, 371 Serra Mall, Stanford, California 94305, USA)

  • William Underwood

    (Energy Bioscience Institute, 130 Calvin Hall, MC 5230)

  • Bhavna Chaudhuri

    (Carnegie Institution for Science)

  • Diane Chermak

    (Carnegie Institution for Science)

  • Ginny Antony

    (Kansas State University)

  • Frank F. White

    (Kansas State University)

  • Shauna C. Somerville

    (Energy Bioscience Institute, 130 Calvin Hall, MC 5230)

  • Mary Beth Mudgett

    (Stanford University, 228A Gilbert Bioscience Building, 371 Serra Mall, Stanford, California 94305, USA)

  • Wolf B. Frommer

    (Carnegie Institution for Science)

Abstract

Sugar efflux transporters are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. Despite broad biological importance, the identity of sugar efflux transporters has remained elusive. Using optical glucose sensors, we identified a new class of sugar transporters, named SWEETs, and show that at least six out of seventeen Arabidopsis, two out of over twenty rice and two out of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport. Arabidopsis SWEET8 is essential for pollen viability, and the rice homologues SWEET11 and SWEET14 are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter. Bacterial symbionts and fungal and bacterial pathogens induce the expression of different SWEET genes, indicating that the sugar efflux function of SWEET transporters is probably targeted by pathogens and symbionts for nutritional gain. The metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary cells.

Suggested Citation

  • Li-Qing Chen & Bi-Huei Hou & Sylvie Lalonde & Hitomi Takanaga & Mara L. Hartung & Xiao-Qing Qu & Woei-Jiun Guo & Jung-Gun Kim & William Underwood & Bhavna Chaudhuri & Diane Chermak & Ginny Antony & Fr, 2010. "Sugar transporters for intercellular exchange and nutrition of pathogens," Nature, Nature, vol. 468(7323), pages 527-532, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7323:d:10.1038_nature09606
    DOI: 10.1038/nature09606
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    Cited by:

    1. Binqi Li & Muhammad Moaaz Ali & Tianxin Guo & Shariq Mahmood Alam & Shaista Gull & Junaid Iftikhar & Ahmed Fathy Yousef & Walid F. A. Mosa & Faxing Chen, 2022. "Genome-Wide Identification, In Silico Analysis and Expression Profiling of SWEET Gene Family in Loquat ( Eriobotrya japonica Lindl.)," Agriculture, MDPI, vol. 12(9), pages 1-17, August.
    2. Mark Löbel & Sacha P. Salphati & Kamel El Omari & Armin Wagner & Stephen J. Tucker & Joanne L. Parker & Simon Newstead, 2022. "Structural basis for proton coupled cystine transport by cystinosin," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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