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L1 retrotransposition in neurons is modulated by MeCP2

Author

Listed:
  • Alysson R. Muotri

    (University of California San Diego, School of Medicine, Stem Cell Program)

  • Maria C. N. Marchetto

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Nicole G. Coufal

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Ruth Oefner

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Gene Yeo

    (University of California San Diego, School of Medicine, Stem Cell Program, 9500 Gilman Dr, La Jolla, California 92093-0695, USA)

  • Kinichi Nakashima

    (Laboratory of Molecular Neuroscience, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0101, Japan)

  • Fred H. Gage

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

Abstract

Retrotransposition in neurons L1 retrotransposons are dynamically regulated and active genomic elements that affect gene expression and neuronal function throughout brain development. According to a new study by Alysson Muotri and colleagues, the absence of MeCP2, a modulator of DNA methylation implicated in several neurodevelopmental disorders, increases L1 retrotransposon activity in rodent models. This increase in susceptibility to L1 retrotransposition is duplicated in iPS cells derived from patients with Rett syndrome. These data correlations suggest that disease-related genetic mutations may influence L1 retrotransposon activity, adding another layer of complexity to our understanding of molecular neurological disorders.

Suggested Citation

  • Alysson R. Muotri & Maria C. N. Marchetto & Nicole G. Coufal & Ruth Oefner & Gene Yeo & Kinichi Nakashima & Fred H. Gage, 2010. "L1 retrotransposition in neurons is modulated by MeCP2," Nature, Nature, vol. 468(7322), pages 443-446, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7322:d:10.1038_nature09544
    DOI: 10.1038/nature09544
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    Cited by:

    1. Bert I. Crawford & Mary Jo Talley & Joshua Russman & James Riddle & Sabrina Torres & Troy Williams & Michelle S. Longworth, 2024. "Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Chen Sun & Kunal Kathuria & Sarah B. Emery & ByungJun Kim & Ian E. Burbulis & Joo Heon Shin & Daniel R. Weinberger & John V. Moran & Jeffrey M. Kidd & Ryan E. Mills & Michael J. McConnell, 2024. "Mapping recurrent mosaic copy number variation in human neurons," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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