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Integrating carbon–halogen bond formation into medicinal plant metabolism

Author

Listed:
  • Weerawat Runguphan

    (Massachusetts Institute of Technology)

  • Xudong Qu

    (Massachusetts Institute of Technology
    Present address: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.)

  • Sarah E. O’Connor

    (Massachusetts Institute of Technology)

Abstract

Gilding the periwinkle Medicinal plants produce a variety of structurally complex, pharmaceutically important products, but generate relatively few halogenated compounds. Runguphan et al. remedy that omission by introducing the biosynthetic machinery responsible for chlorination in soil bacteria into the genome of the periwinkle, Catharanthus roseus. The prokaryotic halogenases function within the plant cells to generate chlorinated tryptophan, which is then utilized by the monoterpene indole alkaloid metabolic pathways to yield chlorinated alkaloids.

Suggested Citation

  • Weerawat Runguphan & Xudong Qu & Sarah E. O’Connor, 2010. "Integrating carbon–halogen bond formation into medicinal plant metabolism," Nature, Nature, vol. 468(7322), pages 461-464, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7322:d:10.1038_nature09524
    DOI: 10.1038/nature09524
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    Cited by:

    1. Kevin B. Reed & Sierra M. Brooks & Jordan Wells & Kristin J. Blake & Minye Zhao & Kira Placido & Simon d’Oelsnitz & Adit Trivedi & Shruti Gadhiyar & Hal S. Alper, 2024. "A modular and synthetic biosynthesis platform for de novo production of diverse halogenated tryptophan-derived molecules," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Yuanwei Gou & Dongfang Li & Minghui Zhao & Mengxin Li & Jiaojiao Zhang & Yilian Zhou & Feng Xiao & Gaofei Liu & Haote Ding & Chenfan Sun & Cuifang Ye & Chang Dong & Jucan Gao & Di Gao & Zehua Bao & Le, 2024. "Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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