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Molecular coupling of Tsix regulation and pluripotency

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  • Pablo Navarro

    (Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    Medical Research Council (MRC) Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh)

  • Andrew Oldfield

    (Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    UMR 7216 Epigénétique et Destin Cellulaire, CNRS/Université Paris Diderot, Case 7042, 75205 Paris Cedex 13, France)

  • Julie Legoupi

    (Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France)

  • Nicola Festuccia

    (Medical Research Council (MRC) Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh)

  • Agnès Dubois

    (Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France)

  • Mikael Attia

    (Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France)

  • Jon Schoorlemmer

    (ARAID Foundation and Instituto Aragonés de Ciencias de la Salud, Facultad de Veterinaria)

  • Claire Rougeulle

    (Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    UMR 7216 Epigénétique et Destin Cellulaire, CNRS/Université Paris Diderot, Case 7042, 75205 Paris Cedex 13, France)

  • Ian Chambers

    (Medical Research Council (MRC) Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh)

  • Philip Avner

    (Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France)

Abstract

Tsix regulation and pluripotency Reprogramming of X-chromosome inactivation during the acquisition of pluripotency is accompanied by repression of Xist, the trigger of X-inactivation, and by upregulation of its antisense counterpart Tsix, which triggers resetting of the Xist locus. In undifferentiated embryonic stem cells, key transcription factors that support pluripotency — Nanog, Oct4 and Sox2 — repress Xist transcription. Here, upregulation of Tsix in embryonic stem cells is shown to depend on a different subset of pluripotency factors — Rex1, Klf4 and c-Myc. Therefore, two distinct embryonic-stem-cell-specific complexes couple reprogramming of X-inactivation to pluripotency.

Suggested Citation

  • Pablo Navarro & Andrew Oldfield & Julie Legoupi & Nicola Festuccia & Agnès Dubois & Mikael Attia & Jon Schoorlemmer & Claire Rougeulle & Ian Chambers & Philip Avner, 2010. "Molecular coupling of Tsix regulation and pluripotency," Nature, Nature, vol. 468(7322), pages 457-460, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7322:d:10.1038_nature09496
    DOI: 10.1038/nature09496
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    Cited by:

    1. Gemma Noviello & Rutger A. F. Gjaltema & Edda G. Schulz, 2023. "CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Teresa Robert-Finestra & Beatrice F. Tan & Hegias Mira-Bontenbal & Erika Timmers & Cristina Gontan & Sarra Merzouk & Benedetto Daniele Giaimo & François Dossin & Wilfred F. J. IJcken & John W. M. Mart, 2021. "SPEN is required for Xist upregulation during initiation of X chromosome inactivation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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