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Rethinking schizophrenia

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  • Thomas R. Insel

    (National Institute of Mental Health)

Abstract

Schizophrenia today: three views of the future Three Perspectives in this issue cover different aspects of the current state of our knowledge about schizophrenia. Thomas Insel, director of the US National Institute of Mental Health in Bethesda, Maryland, outlines a new approach to schizophrenia that could in time lead to new treatments. He calls for schizophrenia to be emphasized as a neurodevelopmental disorder in which psychosis is a late — and potentially curable — stage. Andreas Meyer-Lindenberg, director of the Central Institute of Mental Health in Mannheim, Germany, explains how neuroimaging and other systems-level techniques can help develop future treatment. And Jim van Os, Gunter Kenis and Bart Rutten review our knowledge of the environmental factors that influence schizophrenia risk, and the major challenges that will be involved in teasing them out.

Suggested Citation

  • Thomas R. Insel, 2010. "Rethinking schizophrenia," Nature, Nature, vol. 468(7321), pages 187-193, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09552
    DOI: 10.1038/nature09552
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    Cited by:

    1. Kristian L Toftegaard & Lea Nørgreen Gustafsson & Richard Uwakwe & Ulla A Andersen & Thomas Becker & Graziella Giacometti Bickel & Bernhard Bork & Joachim Cordes & Karel Frasch & Bent Ascanius Jacobs, 2015. "Where are patients who have co-occurring mental and physical diseases located?," International Journal of Social Psychiatry, , vol. 61(5), pages 456-464, August.
    2. Zengpeng Han & Nengsong Luo & Wenyu Ma & Xiaodong Liu & Yuxiang Cai & Jiaxin Kou & Jie Wang & Lei Li & Siqi Peng & Zihong Xu & Wen Zhang & Yuxiang Qiu & Yang Wu & Chaohui Ye & Kunzhang Lin & Fuqiang X, 2023. "AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Xiaxia Xu & Lingzhen Song & Rebecca Kringel & Ileana L. Hanganu-Opatz, 2021. "Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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