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A methyl transferase links the circadian clock to the regulation of alternative splicing

Author

Listed:
  • Sabrina E. Sanchez

    (IFEVA, Facultad de Agronomía, UBA-CONICET)

  • Ezequiel Petrillo

    (IFIBYNE, FCEyN, UBA-CONICET)

  • Esteban J. Beckwith

    (Fundación Instituto Leloir, IIBBA-CONICET)

  • Xu Zhang

    (University of Chicago)

  • Matias L. Rugnone

    (IFEVA, Facultad de Agronomía, UBA-CONICET)

  • C. Esteban Hernando

    (IFEVA, Facultad de Agronomía, UBA-CONICET)

  • Juan C. Cuevas

    (Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB)

  • Micaela A. Godoy Herz

    (IFIBYNE, FCEyN, UBA-CONICET)

  • Ana Depetris-Chauvin

    (Fundación Instituto Leloir, IIBBA-CONICET)

  • Craig G. Simpson

    (Genetics Programme, SCRI, Invergowrie)

  • John W. S. Brown

    (Genetics Programme, SCRI, Invergowrie
    University of Dundee at SCRI)

  • Pablo D. Cerdán

    (Fundación Instituto Leloir, IIBBA-CONICET)

  • Justin O. Borevitz

    (University of Chicago)

  • Paloma Mas

    (Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB)

  • M. Fernanda Ceriani

    (Fundación Instituto Leloir, IIBBA-CONICET)

  • Alberto R. Kornblihtt

    (IFIBYNE, FCEyN, UBA-CONICET)

  • Marcelo J. Yanovsky

    (IFEVA, Facultad de Agronomía, UBA-CONICET
    Fundación Instituto Leloir, IIBBA-CONICET)

Abstract

Time for some RNA editing Various biological processes are driven by the day/night cycle to occur at a certain time of day. One way the circadian system exerts these effects is through post-transcriptional regulation. Sanchez et al. show that PRMT5, a protein that transfers methyl groups onto subunits of the spliceosome — the complex that cuts non-protein-coding stretches from pre-RNA — is regulated by the light/dark cycle. This affects alternative splicing of some genes, making them subject to circadian control. This work shows one way by which the environment alters gene expression.

Suggested Citation

  • Sabrina E. Sanchez & Ezequiel Petrillo & Esteban J. Beckwith & Xu Zhang & Matias L. Rugnone & C. Esteban Hernando & Juan C. Cuevas & Micaela A. Godoy Herz & Ana Depetris-Chauvin & Craig G. Simpson & J, 2010. "A methyl transferase links the circadian clock to the regulation of alternative splicing," Nature, Nature, vol. 468(7320), pages 112-116, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7320:d:10.1038_nature09470
    DOI: 10.1038/nature09470
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    Cited by:

    1. Hao A. Duong & Kenkichi Baba & Jason P. DeBruyne & Alec J. Davidson & Christopher Ehlen & Michael Powell & Gianluca Tosini, 2024. "Environmental circadian disruption re-writes liver circadian proteomes," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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