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Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Author

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  • Kimie Nakagawa

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Yoshihisa Hirota

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Natsumi Sawada

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Naohito Yuge

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Masato Watanabe

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Yuri Uchino

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Naoko Okuda

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Yuka Shimomura

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Yoshitomo Suhara

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

  • Toshio Okano

    (Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan)

Abstract

Key enzyme in vitamin K metabolism Vitamin K, an important factor in blood clotting and bone metabolism, is present in the diet principally as phylloquinone (PK) from plants. One form of the vitamin, menaquinone-4 or MK-4, has a highly specific tissue distribution in the brain, kidney and pancreas in humans and in rats, suggestive of local synthesis from phylloquinone. An enzyme catalysing that synthesis has now been identified: UbiA prenyltransferase containing 1 (UBIAD1) is a human homologue of an Escherichia coli enzyme. Previously its function was unclear, although it is a candidate gene in Schnyder crystalline corneal dystrophy. The discovery of a human MK-4 enzyme able to biosynthesize the hormonally active form of vitamin K is of relevance to work on human vitamin K requirements and bone health.

Suggested Citation

  • Kimie Nakagawa & Yoshihisa Hirota & Natsumi Sawada & Naohito Yuge & Masato Watanabe & Yuri Uchino & Naoko Okuda & Yuka Shimomura & Yoshitomo Suhara & Toshio Okano, 2010. "Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme," Nature, Nature, vol. 468(7320), pages 117-121, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7320:d:10.1038_nature09464
    DOI: 10.1038/nature09464
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    Cited by:

    1. Hongwen Chen & Xiaofeng Qi & Rebecca A. Faulkner & Marc M. Schumacher & Linda M. Donnelly & Russell A. DeBose-Boyd & Xiaochun Li, 2022. "Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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