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Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

Author

Listed:
  • Christel Rouget

    (mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France)

  • Catherine Papin

    (mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France)

  • Anthony Boureux

    (CRBM, UMR5237, Université Montpellier II, CNRS, 1919 route de Mende, 34293 Montpellier, France)

  • Anne-Cécile Meunier

    (mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France)

  • Bénédicte Franco

    (mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France)

  • Nicolas Robine

    (Sloan-Kettering Institute, 1017 Rockefeller Research Laboratories, 1275 York Avenue, New York, New York 10065, USA)

  • Eric C. Lai

    (Sloan-Kettering Institute, 1017 Rockefeller Research Laboratories, 1275 York Avenue, New York, New York 10065, USA)

  • Alain Pelisson

    (RNA Silencing and Control of Transposition, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France)

  • Martine Simonelig

    (mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France)

Abstract

piRNAs keep Nanos in check Small RNAs of the piRNA (Piwi-associated RNA) class have various functions in the germline — repressing transposable elements, maintaining germline stem cells and promoting genome stability. Rouget et al. have now uncovered a function for piRNAs outside the germline, in the fruit fly embryo. Specifically, piRNAs that are complementary to a sequence in the 3′-untranslated region of an mRNA for the embryonic posterior morphogen Nanos facilitate adenylation of the mRNA and its subsequent decay. Without piRNAs, Nanos accumulates and developmental defects result.

Suggested Citation

  • Christel Rouget & Catherine Papin & Anthony Boureux & Anne-Cécile Meunier & Bénédicte Franco & Nicolas Robine & Eric C. Lai & Alain Pelisson & Martine Simonelig, 2010. "Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo," Nature, Nature, vol. 467(7319), pages 1128-1132, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7319:d:10.1038_nature09465
    DOI: 10.1038/nature09465
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    Cited by:

    1. Xiaolong Lv & Wen Xiao & Yana Lai & Zhaozhen Zhang & Hongdao Zhang & Chen Qiu & Li Hou & Qin Chen & Duanduan Wang & Yun Gao & Yuanyuan Song & Xinjia Shui & Qinghua Chen & Ruixin Qin & Shuang Liang & W, 2023. "The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Anne Ramat & Ali Haidar & Céline Garret & Martine Simonelig, 2024. "Spatial organization of translation and translational repression in two phases of germ granules," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Huan Wei & Jie Gao & Di-Hang Lin & Ruirong Geng & Jiaoyang Liao & Tian-Yu Huang & Guanyi Shang & Jiongjie Jing & Zong-Wei Fan & Duo Pan & Zi-Qi Yin & Tianming Li & Xinyu Liu & Shuang Zhao & Chen Chen , 2024. "piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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