IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v467y2010i7314d10.1038_nature09415.html
   My bibliography  Save this article

Gut inflammation provides a respiratory electron acceptor for Salmonella

Author

Listed:
  • Sebastian E. Winter

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • Parameth Thiennimitr

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Faculty of Medicine, Chiang Mai University)

  • Maria G. Winter

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • Brian P. Butler

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • Douglas L. Huseby

    (University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • Robert W. Crawford

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • Joseph M. Russell

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • Charles L. Bevins

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • L. Garry Adams

    (College of Veterinary Medicine, Texas A&M University)

  • Renée M. Tsolis

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • John R. Roth

    (University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

  • Andreas J. Bäumler

    (School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA)

Abstract

Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation react with endogenous, luminal sulphur compounds (thiosulphate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to use tetrathionate as an electron acceptor produce a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen.

Suggested Citation

  • Sebastian E. Winter & Parameth Thiennimitr & Maria G. Winter & Brian P. Butler & Douglas L. Huseby & Robert W. Crawford & Joseph M. Russell & Charles L. Bevins & L. Garry Adams & Renée M. Tsolis & Joh, 2010. "Gut inflammation provides a respiratory electron acceptor for Salmonella," Nature, Nature, vol. 467(7314), pages 426-429, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7314:d:10.1038_nature09415
    DOI: 10.1038/nature09415
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09415
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09415?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gina Paola Rodriguez-Castaño & Federico E Rey & Alejandro Caro-Quintero & Alejandro Acosta-González, 2020. "Gut-derived Flavonifractor species variants are differentially enriched during in vitro incubation with quercetin," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-21, December.
    2. Patrick A McLaughlin & Julie A Bettke & Jason W Tam & Jesse Leeds & James B Bliska & Brian P Butler & Adrianus W M van der Velden, 2019. "Inflammatory monocytes provide a niche for Salmonella expansion in the lumen of the inflamed intestine," PLOS Pathogens, Public Library of Science, vol. 15(7), pages 1-17, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:467:y:2010:i:7314:d:10.1038_nature09415. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.