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Damage-induced phosphorylation of Sld3 is important to block late origin firing

Author

Listed:
  • Jaime Lopez-Mosqueda

    (University of California, San Francisco, San Francisco, California 94158-9001, USA)

  • Nancy L. Maas

    (University of California, San Francisco, San Francisco, California 94158-9001, USA)

  • Zophonias O. Jonsson

    (University of California, Los Angeles, 615 Charles E. Young Dr. South BSRB 377A, Los Angeles, California 90095, USA
    Present address: Institute of Biology, University of Iceland, Sturlugata 7,101-Reykjavik, Iceland.)

  • Lisa G. DeFazio-Eli

    (University of California, San Francisco, San Francisco, California 94158-9001, USA)

  • James Wohlschlegel

    (University of California, Los Angeles, 615 Charles E. Young Dr. South BSRB 377A, Los Angeles, California 90095, USA)

  • David P. Toczyski

    (University of California, San Francisco, San Francisco, California 94158-9001, USA)

Abstract

Stop at the intra-S checkpoint Two classes of kinases, CDK and DDK, facilitate the initiation of DNA replication in S phase. In two studies, the Diffley and Toczyski labs show that when damage is sensed, another kinase — the checkpoint kinase Rad53 — halts replication by inhibiting both the CDK and DDK pathways through the phosphorylation of Sld3 and Dbf4, respectively. These results reveal that regulation of the firing of origins is the means by which the intra-S checkpoint slows S phase.

Suggested Citation

  • Jaime Lopez-Mosqueda & Nancy L. Maas & Zophonias O. Jonsson & Lisa G. DeFazio-Eli & James Wohlschlegel & David P. Toczyski, 2010. "Damage-induced phosphorylation of Sld3 is important to block late origin firing," Nature, Nature, vol. 467(7314), pages 479-483, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7314:d:10.1038_nature09377
    DOI: 10.1038/nature09377
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    Cited by:

    1. Matthew Day & Bilal Tetik & Milena Parlak & Yasser Almeida-Hernández & Markus Räschle & Farnusch Kaschani & Heike Siegert & Anika Marko & Elsa Sanchez-Garcia & Markus Kaiser & Isabel A. Barker & Laure, 2024. "TopBP1 utilises a bipartite GINS binding mode to support genome replication," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Karl-Uwe Reusswig & Julia Bittmann & Martina Peritore & Mathilde Courtes & Benjamin Pardo & Michael Wierer & Matthias Mann & Boris Pfander, 2022. "Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Jiaxuan Cheng & Ningning Li & Yunjing Huo & Shangyu Dang & Bik-Kwoon Tye & Ning Gao & Yuanliang Zhai, 2022. "Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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