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Oligomeric organization of the B-cell antigen receptor on resting cells

Author

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  • Jianying Yang

    (Centre for Biological Signalling Studies BIOSS, Albert-Ludwigs-Universität Freiburg, Faculty of Biology, Albert-Ludwigs-Universität Freiburg and Max Planck Institute for Immunobiology, Stübeweg 51, 79108 Freiburg, Germany)

  • Michael Reth

    (Centre for Biological Signalling Studies BIOSS, Albert-Ludwigs-Universität Freiburg, Faculty of Biology, Albert-Ludwigs-Universität Freiburg and Max Planck Institute for Immunobiology, Stübeweg 51, 79108 Freiburg, Germany)

Abstract

B cells at rest A B lymphocyte has the potential to respond to a vast number of antigens thanks to the 120,000 or so B-cell antigen receptor (BCR) complexes on its cell surface. Much work has been done on the nature of the BCR activation process. Here, Jianying Yang and Michael Reth look at the status of the BCR before activation. Their data support a model in which most BCR complexes on resting B cells reside in closed (autoinhibited) oligomers. The authors propose that it is the opening of closed BCR oligomers — rather than the cross-linking of monomers — that drives B cell activation.

Suggested Citation

  • Jianying Yang & Michael Reth, 2010. "Oligomeric organization of the B-cell antigen receptor on resting cells," Nature, Nature, vol. 467(7314), pages 465-469, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7314:d:10.1038_nature09357
    DOI: 10.1038/nature09357
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    Cited by:

    1. Alexey Ferapontov & Marjan Omer & Isabelle Baudrexel & Jesper Sejrup Nielsen & Daniel Miotto Dupont & Kristian Juul-Madsen & Philipp Steen & Alexandra S. Eklund & Steffen Thiel & Thomas Vorup-Jensen &, 2023. "Antigen footprint governs activation of the B cell receptor," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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