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Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo

Author

Listed:
  • Michael R. Elliott

    (Beirne B. Carter Center for Immunology Research, University of Virginia
    Center for Cell Clearance, University of Virginia)

  • Shuqiu Zheng

    (University of Virginia)

  • Daeho Park

    (Beirne B. Carter Center for Immunology Research, University of Virginia
    Center for Cell Clearance, University of Virginia)

  • Robin I. Woodson

    (University of Virginia)

  • Michael A. Reardon

    (University of Virginia)

  • Ignacio J. Juncadella

    (Beirne B. Carter Center for Immunology Research, University of Virginia
    Center for Cell Clearance, University of Virginia)

  • Jason M. Kinchen

    (Center for Cell Clearance, University of Virginia
    University of Virginia)

  • Jun Zhang

    (University of Virginia)

  • Jeffrey J. Lysiak

    (Center for Cell Clearance, University of Virginia
    University of Virginia)

  • Kodi S. Ravichandran

    (Beirne B. Carter Center for Immunology Research, University of Virginia
    Center for Cell Clearance, University of Virginia
    University of Virginia)

Abstract

Clearance of apoptotic germ cells by ELMO1 Apoptotic cell death is crucial for tissue development and function and occurs throughout mammalian life. Removal of dying cells by phagocytes is important to prevent tissue dysfunction, but the mechanisms that regulate clearance of dying cells in vivo remain unclear. In this study, Elliott et al. reveal a crucial role for a conserved engulfment protein, ELMO1, in the phagocytic clearance of apoptotic germ cells by Sertoli cells and the maintenance of normal testicular homeostasis.

Suggested Citation

  • Michael R. Elliott & Shuqiu Zheng & Daeho Park & Robin I. Woodson & Michael A. Reardon & Ignacio J. Juncadella & Jason M. Kinchen & Jun Zhang & Jeffrey J. Lysiak & Kodi S. Ravichandran, 2010. "Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo," Nature, Nature, vol. 467(7313), pages 333-337, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7313:d:10.1038_nature09356
    DOI: 10.1038/nature09356
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    Cited by:

    1. Viviane Tran & Sarah Nahlé & Amélie Robert & Inès Desanlis & Ryan Killoran & Sophie Ehresmann & Marie-Pier Thibault & David Barford & Kodi S. Ravichandran & Martin Sauvageau & Matthew J. Smith & Marie, 2022. "Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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