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A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

Author

Listed:
  • Nicolas Manel

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
    CNRS-UMR5535, Institut de Génétique Moléculaire de Montpellier, Université Montpellier I and II)

  • Brandon Hogstad

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
    Howard Hughes Medical Institute, New York University School of Medicine)

  • Yaming Wang

    (New York University School of Medicine)

  • David E. Levy

    (New York University School of Medicine)

  • Derya Unutmaz

    (New York University School of Medicine)

  • Dan R. Littman

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
    Howard Hughes Medical Institute, New York University School of Medicine
    New York University School of Medicine)

Abstract

HIV-1 in dendritic cells HIV-1 (human immunodeficiency virus 1) infection fails to induce interferon in the cells that it infects, but the underlying mechanisms involved are undefined. Dendritic cells — immune cells found in skin, mucosa and lymph tissues — mediate the innate detection of pathogens and the activation of other immune cells involved in specific adaptive immunity. But not for HIV. Dendritic cells are resistant to infection by HIV, although they do bind to the virus and are thought to facilitate the infection of T-helper cells. Now it is shown that when the usual block to HIV infection is bypassed in dendritic cells — by exposure to the Vpx accessory protein from the simian immunodeficiency virus SIVmac — HIV does induce a type I interferon response and T-cell activation. The virulence of HIV-1 may be related to its ability to evade innate immunity by staying out of dendritic cells, and the manipulation of that strategy may be of relevance to vaccine design.

Suggested Citation

  • Nicolas Manel & Brandon Hogstad & Yaming Wang & David E. Levy & Derya Unutmaz & Dan R. Littman, 2010. "A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells," Nature, Nature, vol. 467(7312), pages 214-217, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7312:d:10.1038_nature09337
    DOI: 10.1038/nature09337
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    Cited by:

    1. Lisa D. J. Schiffelers & Yonas M. Tesfamariam & Lea-Marie Jenster & Stefan Diehl & Sophie C. Binder & Sabine Normann & Jonathan Mayr & Steffen Pritzl & Elena Hagelauer & Anja Kopp & Assaf Alon & Matth, 2024. "Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Caroline Passaes & Delphine Desjardins & Anaïs Chapel & Valérie Monceaux & Julien Lemaitre & Adeline Mélard & Federico Perdomo-Celis & Cyril Planchais & Maël Gourvès & Nastasia Dimant & Annie David & , 2024. "Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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