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OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

Author

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  • Pedro P. Medina

    (Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520, USA)

  • Mona Nolde

    (Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520, USA
    Present address: Department of Cell Biology, Yale University School of Medicine, PO Box 208002, New Haven, Connecticut 06520, USA.)

  • Frank J. Slack

    (Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520, USA)

Abstract

Tumour addicted to oncomiR MicroRNAs (miRNAs) — small RNA molecules that regulate gene expression and have an important role in establishing cell identity — have been linked to human cancers, where they are referred to as oncomiRs. One model of cancer development proposes that proliferating cells become 'addicted' to activating mutations in an oncogene, and it has been suggested that tumours may also become dependent on oncomiRs. Work in mice that were engineered to conditionally express microRNA-21 (miR-21), which is overexpressed in most tumour types so far analysed, now shows that miR-21 induces pre-B-cell lymphoma. In the absence of miR-21, malignant cells undergo apoptosis and regress, as would be expected if they were addicted to its presence. The pharmacological inactivation of 'oncomiR-21' and other similar miRNAs may therefore be of therapeutic benefit.

Suggested Citation

  • Pedro P. Medina & Mona Nolde & Frank J. Slack, 2010. "OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma," Nature, Nature, vol. 467(7311), pages 86-90, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7311:d:10.1038_nature09284
    DOI: 10.1038/nature09284
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    Cited by:

    1. Youjia Hua & Shiwei Duan & Andrea E Murmann & Niels Larsen & Jørgen Kjems & Anders H Lund & Marcus E Peter, 2011. "miRConnect: Identifying Effector Genes of miRNAs and miRNA Families in Cancer Cells," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-16, October.
    2. Wenjie Zhu & Binghe Xu, 2014. "MicroRNA-21 Identified as Predictor of Cancer Outcome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-7, August.

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