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Amygdalar and hippocampal substrates of anxious temperament differ in their heritability

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  • Jonathan A. Oler

    (University of Wisconsin-Madison
    HealthEmotions Research Institute, University of Wisconsin-Madison)

  • Andrew S. Fox

    (University of Wisconsin-Madison
    Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison)

  • Steven E. Shelton

    (University of Wisconsin-Madison
    HealthEmotions Research Institute, University of Wisconsin-Madison)

  • Jeffrey Rogers

    (Baylor College of Medicine
    Southwest Foundation for Biomedical Research)

  • Thomas D. Dyer

    (Southwest Foundation for Biomedical Research)

  • Richard J. Davidson

    (University of Wisconsin-Madison
    University of Wisconsin-Madison
    HealthEmotions Research Institute, University of Wisconsin-Madison
    Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison)

  • Wendy Shelledy

    (Southwest Foundation for Biomedical Research)

  • Terrence R. Oakes

    (Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison)

  • John Blangero

    (Southwest Foundation for Biomedical Research)

  • Ned H. Kalin

    (University of Wisconsin-Madison
    University of Wisconsin-Madison
    HealthEmotions Research Institute, University of Wisconsin-Madison
    Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison)

Abstract

Genetic factors in anxiety An anxious temperament in both humans and monkeys is evident from infanthood, is an important risk factor for later psychopathology, and is known to be heritable. In a large-scale study combining imaging with genetics, Oler et al. characterize the neural circuitry associated with this trait and the extent to which the function of this circuit is heritable. They scanned more than 200 related monkeys from a single-family pedigree using positron emission tomography after exposing the monkeys to a mildly stressful situation. Activation in both the amygdala and hippocampus was predictive of anxious temperament, but heritability of hippocampal activity was greater than that for amygdala. This suggests that there may be different effects of genes and environment on the function of these two regions in anxious temperament, and provides new insights into the genetic risk for anxiety and depressive disorders.

Suggested Citation

  • Jonathan A. Oler & Andrew S. Fox & Steven E. Shelton & Jeffrey Rogers & Thomas D. Dyer & Richard J. Davidson & Wendy Shelledy & Terrence R. Oakes & John Blangero & Ned H. Kalin, 2010. "Amygdalar and hippocampal substrates of anxious temperament differ in their heritability," Nature, Nature, vol. 466(7308), pages 864-868, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7308:d:10.1038_nature09282
    DOI: 10.1038/nature09282
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    Cited by:

    1. R. Croston & C.L. Branch & D.Y. Kozlovsky & R. Dukas & V.V. Pravosudov, 2015. "Heritability and the evolution of cognitive traits," Behavioral Ecology, International Society for Behavioral Ecology, vol. 26(6), pages 1447-1459.

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