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Regulation of myeloid leukaemia by the cell-fate determinant Musashi

Author

Listed:
  • Takahiro Ito

    (Duke University Medical Center)

  • Hyog Young Kwon

    (Duke University Medical Center)

  • Bryan Zimdahl

    (Duke University Medical Center)

  • Kendra L. Congdon

    (Duke University Medical Center)

  • Jordan Blum

    (Duke University Medical Center)

  • William E. Lento

    (Duke University Medical Center)

  • Chen Zhao

    (Duke University Medical Center)

  • Anand Lagoo

    (Duke University Medical Center)

  • Gareth Gerrard

    (Imperial College London, Hammersmith Hospital)

  • Letizia Foroni

    (Imperial College London, Hammersmith Hospital)

  • John Goldman

    (Imperial College London, Hammersmith Hospital)

  • Harriet Goh

    (Seoul St Mary’s Hospital, The Catholic University of Korea)

  • Soo-Hyun Kim

    (Seoul St Mary’s Hospital, The Catholic University of Korea)

  • Dong-Wook Kim

    (Seoul St Mary’s Hospital, The Catholic University of Korea)

  • Charles Chuah

    (Singapore General Hospital, Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School)

  • Vivian G. Oehler

    (Fred Hutchinson Cancer Research Center)

  • Jerald P. Radich

    (Fred Hutchinson Cancer Research Center)

  • Craig T. Jordan

    (James P. Wilmot Cancer Center, University of Rochester School of Medicine)

  • Tannishtha Reya

    (Duke University Medical Center)

Abstract

Blocking leukaemia progress The molecular basis of the progression of chronic myeloid leukaemia from the chronic stage to the acute phase is poorly understood. Now, work in mouse models of chronic myeloid leukaemia shows that this progression is controlled by the cell fate regulator Musashi2, which in turn regulates Numb, Notch and p53 to block cellular differentiation. Musashi2 expression can be increased by aberrant transcription factors found in leukaemia and is observed during cancer progression in human patients with leukaemia, where it is associated with poorer prognosis. This raises the possibility that modulating Musashi–Numb associated signalling may serve as a new approach to therapies against this disease.

Suggested Citation

  • Takahiro Ito & Hyog Young Kwon & Bryan Zimdahl & Kendra L. Congdon & Jordan Blum & William E. Lento & Chen Zhao & Anand Lagoo & Gareth Gerrard & Letizia Foroni & John Goldman & Harriet Goh & Soo-Hyun , 2010. "Regulation of myeloid leukaemia by the cell-fate determinant Musashi," Nature, Nature, vol. 466(7307), pages 765-768, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7307:d:10.1038_nature09171
    DOI: 10.1038/nature09171
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    Cited by:

    1. Tatiana Erazo & Chiara M. Evans & Daniel Zakheim & Eren L. Chu & Alice Yunsi Refermat & Zahra Asgari & Xuejing Yang & Mariana Silva Ferreira & Sanjoy Mehta & Marco Vincenzo Russo & Andrea Knezevic & X, 2022. "TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Wenxue Ma & Alejandro Gutierrez & Daniel J Goff & Ifat Geron & Anil Sadarangani & Christina A M Jamieson & Angela C Court & Alice Y Shih & Qingfei Jiang & Christina C Wu & Kang Li & Kristen M Smith & , 2012. "NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-14, June.
    3. Michelle M. Kameda-Smith & Helen Zhu & En-Ching Luo & Yujin Suk & Agata Xella & Brian Yee & Chirayu Chokshi & Sansi Xing & Frederick Tan & Raymond G. Fox & Ashley A. Adile & David Bakhshinyan & Kevin , 2022. "Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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