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Cross-species genomics matches driver mutations and cell compartments to model ependymoma

Author

Listed:
  • Robert A. Johnson

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Karen D. Wright

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Helen Poppleton

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Kumarasamypet M. Mohankumar

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • David Finkelstein

    (Hartwell Centre for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Stanley B. Pounds

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Vikki Rand

    (Northern Institute for Cancer Research, University of Newcastle upon Tyne)

  • Sarah E. S. Leary

    (Hematology-Oncology, Seattle Children's Hospital)

  • Elsie White

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Christopher Eden

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Twala Hogg

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Paul Northcott

    (Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M4N 1X8, Canada)

  • Stephen Mack

    (Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M4N 1X8, Canada)

  • Geoffrey Neale

    (Hartwell Centre for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Yong-Dong Wang

    (Hartwell Centre for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Beth Coyle

    (Children’s Brain Tumour Research Centre, University of Nottingham)

  • Jennifer Atkinson

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Mariko DeWire

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Tanya A. Kranenburg

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Yancey Gillespie

    (University of Alabama)

  • Jeffrey C. Allen

    (New York University, Langone Medical Center)

  • Thomas Merchant

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Fredrick A. Boop

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Robert. A. Sanford

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Amar Gajjar

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • David W. Ellison

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

  • Michael D. Taylor

    (Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M4N 1X8, Canada)

  • Richard G. Grundy

    (Children’s Brain Tumour Research Centre, University of Nottingham)

  • Richard J. Gilbertson

    (St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA)

Abstract

Tumour diversity Ependymoma is a type of neural tumour that arises throughout the central nervous system. Using comparative transcriptomics in mouse and human tumours, Johnson et al. home in on mutations that are specific to individual tumour subgroups. In the course of their study, the authors generate the first mouse model of ependymoma and demonstrate the power of interspecific genomic comparisons to interrogate cancer subgroups.

Suggested Citation

  • Robert A. Johnson & Karen D. Wright & Helen Poppleton & Kumarasamypet M. Mohankumar & David Finkelstein & Stanley B. Pounds & Vikki Rand & Sarah E. S. Leary & Elsie White & Christopher Eden & Twala Ho, 2010. "Cross-species genomics matches driver mutations and cell compartments to model ependymoma," Nature, Nature, vol. 466(7306), pages 632-636, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7306:d:10.1038_nature09173
    DOI: 10.1038/nature09173
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    Citations

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    Cited by:

    1. Min Kyung Lee & Nasim Azizgolshani & Joshua A. Shapiro & Lananh N. Nguyen & Fred W. Kolling & George J. Zanazzi & Hildreth Robert Frost & Brock C. Christensen, 2024. "Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumors," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Xi Lu & Naga Prathyusha Maturi & Malin Jarvius & Irem Yildirim & Yonglong Dang & Linxuan Zhao & Yuan Xie & E-Jean Tan & Pengwei Xing & Rolf Larsson & Mårten Fryknäs & Lene Uhrbom & Xingqi Chen, 2022. "Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Rachael G. Aubin & Emma C. Troisi & Javier Montelongo & Adam N. Alghalith & Maclean P. Nasrallah & Mariarita Santi & Pablo G. Camara, 2022. "Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Qianqian Zhang & Sijin Cheng & Yongzhi Wang & Mengdi Wang & Yufeng Lu & Zengqi Wen & Yuxin Ge & Qiang Ma & Youqiao Chen & Yaowu Zhang & Ren Cao & Min Li & Weihao Liu & Bo Wang & Qian Wu & Wenqing Jia , 2021. "Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    5. Sibo Zhao & Jia Li & Huiyuan Zhang & Lin Qi & Yuchen Du & Mari Kogiso & Frank K. Braun & Sophie Xiao & Yulun Huang & Jianfang Li & Wan-Yee Teo & Holly Lindsay & Patricia Baxter & Jack M. F. Su & Adeku, 2022. "Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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