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PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

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  • Wen Liu

    (Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Graduate Program in Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Bogdan Tanasa

    (Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Kellogg School of Science and Technology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Oksana V. Tyurina

    (Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Tian Yuan Zhou

    (Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Reto Gassmann

    (University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Wei Ting Liu

    (University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Kenneth A. Ohgi

    (Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Chris Benner

    (University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Ivan Garcia-Bassets

    (Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Aneel K. Aggarwal

    (Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, New York 10029, USA)

  • Arshad Desai

    (University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Pieter C. Dorrestein

    (University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Christopher K. Glass

    (University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Michael G. Rosenfeld

    (Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

Abstract

Histone demethylase activity of PHF8 Mutations in the PHF8 gene, which encodes the plant homeo domain (PHD) finger protein 8, are connected to X-linked mental retardation associated with cleft lip and cleft palate. Two groups now report that the PHF8 protein is a histone demethylase with activity against H4K20me1 (histone H4 lysine 20). Qi et al. report a role for PHF8 in regulating gene expression, as well as in neuronal cell survival and craniofacial development in zebrafish. The results suggest there may be a link between histone methylation dynamics and X-linked mental retardation. Liu et al. show that PHF8 is linked to two distinct events during cell-cycle progression. PHF8 is recruited to the promoters of G1/S-phase genes where it removes H4K20me1 and contributes to gene activation, whereas dissociation of PHF8 from chromatin in prophase allows H4K20me1 to accumulate during mitosis.

Suggested Citation

  • Wen Liu & Bogdan Tanasa & Oksana V. Tyurina & Tian Yuan Zhou & Reto Gassmann & Wei Ting Liu & Kenneth A. Ohgi & Chris Benner & Ivan Garcia-Bassets & Aneel K. Aggarwal & Arshad Desai & Pieter C. Dorres, 2010. "PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression," Nature, Nature, vol. 466(7305), pages 508-512, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7305:d:10.1038_nature09272
    DOI: 10.1038/nature09272
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    Cited by:

    1. Yanan Liu & Longmiao Hu & Zhengzhen Wu & Kun Yuan & Guangliang Hong & Zhengke Lian & Juanjuan Feng & Na Li & Dali Li & Jiemin Wong & Jiekai Chen & Mingyao Liu & Jiangping He & Xiufeng Pang, 2023. "Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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