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Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

Author

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  • Yunkun Wu

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA)

  • Yi Yang

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA)

  • Sheng Ye

    (Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China)

  • Youxing Jiang

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA)

Abstract

Gating ring structure High-conductance Ca2+-gated K+ (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release. In this study, Yunkun Wu et al. report the X-ray crystal structure of the entire intracellular cytoplasmic region of the human BK channel in a Ca2+-free state. The authors 'docked' a voltage-gated K+ channel pore of known structure onto the gating ring to generate a structural model for the full BK channel.

Suggested Citation

  • Yunkun Wu & Yi Yang & Sheng Ye & Youxing Jiang, 2010. "Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel," Nature, Nature, vol. 466(7304), pages 393-397, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7304:d:10.1038_nature09252
    DOI: 10.1038/nature09252
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    Cited by:

    1. Tobias Raisch & Andreas Brockmann & Ulrich Ebbinghaus-Kintscher & Jörg Freigang & Oliver Gutbrod & Jan Kubicek & Barbara Maertens & Oliver Hofnagel & Stefan Raunser, 2021. "Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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