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A random cell motility gradient downstream of FGF controls elongation of an amniote embryo

Author

Listed:
  • Bertrand Bénazéraf

    (Howard Hughes Medical Institute
    Stowers Institute for Medical Research
    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg)

  • Paul Francois

    (Center for Studies in Physics and Biology, The Rockefeller University)

  • Ruth E. Baker

    (Centre for Mathematical Biology, Mathematical Institute, University of Oxford)

  • Nicolas Denans

    (Stowers Institute for Medical Research
    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg)

  • Charles D. Little

    (University of Kansas Medical Center)

  • Olivier Pourquié

    (Howard Hughes Medical Institute
    Stowers Institute for Medical Research
    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg
    University of Kansas Medical Center)

Abstract

Controlling embryonic growth Most animal embryos grow through cell accumulation in a posterior growth zone, but the morphogenic forces that control the formation and directionality of the growth are unknown. Based on a study of axis elongation during formation of the trunk and tail structures in the chicken embryo, Bénazéraf et al. propose that tissue elongation in response to signalling mediated by fibroblast growth factor is a property emerging from the collective regulation of graded, random cell motion rather than by the regulation of directionality of individual cellular movements.

Suggested Citation

  • Bertrand Bénazéraf & Paul Francois & Ruth E. Baker & Nicolas Denans & Charles D. Little & Olivier Pourquié, 2010. "A random cell motility gradient downstream of FGF controls elongation of an amniote embryo," Nature, Nature, vol. 466(7303), pages 248-252, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7303:d:10.1038_nature09151
    DOI: 10.1038/nature09151
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    Cited by:

    1. Nigel C Harrison & Ruth Diez del Corral & Bakhtier Vasiev, 2011. "Coordination of Cell Differentiation and Migration in Mathematical Models of Caudal Embryonic Axis Extension," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-18, July.
    2. Susan D Hester & Julio M Belmonte & J Scott Gens & Sherry G Clendenon & James A Glazier, 2011. "A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation," PLOS Computational Biology, Public Library of Science, vol. 7(10), pages 1-32, October.

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