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Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

Author

Listed:
  • Alexander D. Boiko

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304-5542, USA)

  • Olga V. Razorenova

    (Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA)

  • Matt van de Rijn

    (Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA)

  • Susan M. Swetter

    (Pigmented Lesion and Melanoma Program, Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA
    Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA)

  • Denise L. Johnson

    (Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA
    Present address: St. Francis Hospital, Indianapolis, Indiana 46237, USA.)

  • Daphne P. Ly

    (Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA
    Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5118, USA)

  • Paris D. Butler

    (Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA
    Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5118, USA)

  • George P. Yang

    (Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA
    Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5118, USA)

  • Benzion Joshua

    (Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA)

  • Michael J. Kaplan

    (Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA)

  • Michael T. Longaker

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304-5542, USA
    Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA
    Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5118, USA)

  • Irving L. Weissman

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304-5542, USA
    Stanford University Medical Center, Stanford Cancer Center, Stanford, California 94305-5118, USA)

Abstract

A marker for cancer stem cells A number of studies have reported the existence of cancer stem cells in human melanomas, each one capable of producing a tumour. Boiko et al. examined a broad spectrum of clinical samples taken from melanomas and report that the neural crest stem-cell marker CD271 is a marker for cancer stem cells, allowing the identification and prospective isolation of melanoma cancer stem cells.

Suggested Citation

  • Alexander D. Boiko & Olga V. Razorenova & Matt van de Rijn & Susan M. Swetter & Denise L. Johnson & Daphne P. Ly & Paris D. Butler & George P. Yang & Benzion Joshua & Michael J. Kaplan & Michael T. Lo, 2010. "Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271," Nature, Nature, vol. 466(7302), pages 133-137, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7302:d:10.1038_nature09161
    DOI: 10.1038/nature09161
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    Cited by:

    1. Josefine Radke & Elisa Schumann & Julia Onken & Randi Koll & Güliz Acker & Bohdan Bodnar & Carolin Senger & Sascha Tierling & Markus Möbs & Peter Vajkoczy & Anna Vidal & Sandra Högler & Petra Kodajova, 2022. "Decoding molecular programs in melanoma brain metastases," Nature Communications, Nature, vol. 13(1), pages 1-24, December.

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