IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v466y2010i7302d10.1038_nature09114.html
   My bibliography  Save this article

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

Author

Listed:
  • Lynn Petukhova

    (Columbia University, New York, New York 10032, USA)

  • Madeleine Duvic

    (M. D. Anderson Cancer Center, Houston, Texas 77030, USA)

  • Maria Hordinsky

    (University of Minnesota, Minneapolis, Minnesota 55455, USA)

  • David Norris

    (University of Colorado, Denver, Colorado 80010, USA)

  • Vera Price

    (UCSF, San Francisco, California 94115, USA)

  • Yutaka Shimomura

    (Columbia University, New York, New York 10032, USA)

  • Hyunmi Kim

    (Columbia University, New York, New York 10032, USA)

  • Pallavi Singh

    (Columbia University, New York, New York 10032, USA)

  • Annette Lee

    (The Feinstein Institute for Medical Research, North Shore LIJHS, Manhasset, New York 11030, USA)

  • Wei V. Chen

    (M. D. Anderson Cancer Center, Houston, Texas 77030, USA)

  • Katja C. Meyer

    (University of Lübeck)

  • Ralf Paus

    (University of Lübeck
    School of Translational Medicine, University of Manchester)

  • Colin A. B. Jahoda

    (University of Durham)

  • Christopher I. Amos

    (M. D. Anderson Cancer Center, Houston, Texas 77030, USA)

  • Peter K. Gregersen

    (The Feinstein Institute for Medical Research, North Shore LIJHS, Manhasset, New York 11030, USA)

  • Angela M. Christiano

    (Columbia University, New York, New York 10032, USA
    Columbia University, New York, New York 10032, USA)

Abstract

Alopecia areata genetics The genetic basis of alopecia areata, a common autoimmune disease that causes disfiguring hair loss due to the collapse of immune privilege of the hair follicle, is largely unknown. A genome-wide association study has now identified several susceptibility loci for alopecia areata, most of them clustered into eight genomic regions. The spectrum of gene activities affected implies the involvement of both acquired and innate immunity in the condition. Among significant associations are the ULBP genes that encode activating ligands for the natural killer cell receptor NKG2D, which have not been previously linked to autoimmune disease.

Suggested Citation

  • Lynn Petukhova & Madeleine Duvic & Maria Hordinsky & David Norris & Vera Price & Yutaka Shimomura & Hyunmi Kim & Pallavi Singh & Annette Lee & Wei V. Chen & Katja C. Meyer & Ralf Paus & Colin A. B. Ja, 2010. "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity," Nature, Nature, vol. 466(7302), pages 113-117, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7302:d:10.1038_nature09114
    DOI: 10.1038/nature09114
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09114
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09114?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Fatma N. Hamed & Andrew J. G. McDonagh & Sarah Almaghrabi & Youssef Bakri & Andrew G. Messenger & Rachid Tazi-Ahnini, 2018. "Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients," IJERPH, MDPI, vol. 15(12), pages 1-19, December.
    2. Kun-Ju Zhu & Yong-Mei Lv & Xian-Yong Yin & Zai-Xing Wang & Liang-Dan Sun & Su-Min He & Hui Cheng & Da-Yan Hu & Zheng Zhang & Yang Li & Xian-Bo Zuo & You-Wen Zhou & Sen Yang & Xing Fan & Xue-Jun Zhang , 2011. "Psoriasis Regression Analysis of MHC Loci Identifies Shared Genetic Variants with Vitiligo," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-7, November.
    3. Stephanie O. Erjavec & Sahar Gelfman & Alexa R. Abdelaziz & Eunice Y. Lee & Isha Monga & Anna Alkelai & Iuliana Ionita-Laza & Lynn Petukhova & Angela M. Christiano, 2022. "Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:466:y:2010:i:7302:d:10.1038_nature09114. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.