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Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

Author

Listed:
  • Megan T. Baldridge

    (Baylor College of Medicine, Houston, Texas 77030, USA)

  • Katherine Y. King

    (Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Nathan C. Boles

    (Baylor College of Medicine, Houston, Texas 77030, USA)

  • David C. Weksberg

    (Baylor College of Medicine, Houston, Texas 77030, USA)

  • Margaret A. Goodell

    (Baylor College of Medicine, Houston, Texas 77030, USA
    Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA
    Baylor College of Medicine, Houston, Texas 77030, USA)

Abstract

Response to chronic bacterial infection Using a mouse model of bacterial infection, Baldridge et al. show that infection with Mycobacterium avium exerts a powerful stimulatory effect on haematopoietic stem cells, and that this stimulation is mediated by interferon-γ. Circulating immune cells in the blood are consumed during infection, and this work suggests that primitive stem cells in the marrow have a role in their replacement. These findings have implications for the use of interferon-γ as a therapeutic agent during chronic infections such as HIV/AIDS or tuberculosis and for recovery from bone marrow transplantation.

Suggested Citation

  • Megan T. Baldridge & Katherine Y. King & Nathan C. Boles & David C. Weksberg & Margaret A. Goodell, 2010. "Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection," Nature, Nature, vol. 465(7299), pages 793-797, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7299:d:10.1038_nature09135
    DOI: 10.1038/nature09135
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    Cited by:

    1. Yu-Jung Tseng & Yuki Kageyama & Rebecca L. Murdaugh & Ayumi Kitano & Jong Hwan Kim & Kevin A. Hoegenauer & Jonathan Tiessen & Mackenzie H. Smith & Hidetaka Uryu & Koichi Takahashi & James F. Martin & , 2024. "Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Tiago C. Luis & Nikolaos Barkas & Joana Carrelha & Alice Giustacchini & Stefania Mazzi & Ruggiero Norfo & Bishan Wu & Affaf Aliouat & Jose A. Guerrero & Alba Rodriguez-Meira & Tiphaine Bouriez-Jones &, 2023. "Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Jacqueline Feyen & Zhen Ping & Lanpeng Chen & Claire Dijk & Tim V. D. Tienhoven & Paulina M. H. Strien & Remco M. Hoogenboezem & Michiel J. W. Wevers & Mathijs A. Sanders & Ivo P. Touw & Marc H. G. P., 2022. "Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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