Author
Listed:
- Marie-Liesse Asselin-Labat
(The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)
- François Vaillant
(The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)
- Julie M. Sheridan
(The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)
- Bhupinder Pal
(The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)
- Di Wu
(The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
The University of Melbourne, Parkville, Victoria 3010, Australia)
- Evan R. Simpson
(Prince Henry’s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia)
- Hisataka Yasuda
(Nagahama Institute for Biochemical Science, Oriental Yeast Company, Nagahama, Shiga 526-0804, Japan)
- Gordon K. Smyth
(The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
The University of Melbourne, Parkville, Victoria 3010, Australia)
- T. John Martin
(St Vincent’s Institute, Fitzroy, Victoria 3065, Australia)
- Geoffrey J. Lindeman
(The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
The University of Melbourne, Parkville, Victoria 3010, Australia)
- Jane E. Visvader
(The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
The University of Melbourne, Parkville, Victoria 3010, Australia)
Abstract
Mammary stem cell control The ovarian hormones oestrogen and progesterone are involved in a complicated series of interactions in the mammary glands from the beginning of puberty to the menopause. Many of these changes are associated with cell proliferation, and breast cancer can result when errors occur. Two studies in this issue examine the effects of oestrogen and progesterone on mouse mammary stem cell (MaSC) function. They find that MaSC numbers decrease in virgin mice in the absence of both hormones due to ovariectomy or drug blockade, but increase with oestrogen and progesterone treatment. In addition, both groups implicate RANKL, a progesterone target known to be involved in bone remodelling and mammary gland formation, as an intermediary in the MaSC response to progesterone.
Suggested Citation
Marie-Liesse Asselin-Labat & François Vaillant & Julie M. Sheridan & Bhupinder Pal & Di Wu & Evan R. Simpson & Hisataka Yasuda & Gordon K. Smyth & T. John Martin & Geoffrey J. Lindeman & Jane E. Visva, 2010.
"Control of mammary stem cell function by steroid hormone signalling,"
Nature, Nature, vol. 465(7299), pages 798-802, June.
Handle:
RePEc:nat:nature:v:465:y:2010:i:7299:d:10.1038_nature09027
DOI: 10.1038/nature09027
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