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Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana

Author

Listed:
  • Marco Todesco

    (Max Planck Institute for Developmental Biology)

  • Sureshkumar Balasubramanian

    (Max Planck Institute for Developmental Biology
    Present addresses: School of Biological Sciences, University of Queensland, St Lucia, Queensland 4072, Australia (S.B., S.S.); Lewis-Sigler Institute, Princeton University, Princeton, New Jersey 08544, USA (T.T.H.).)

  • Tina T. Hu

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
    Present addresses: School of Biological Sciences, University of Queensland, St Lucia, Queensland 4072, Australia (S.B., S.S.); Lewis-Sigler Institute, Princeton University, Princeton, New Jersey 08544, USA (T.T.H.).)

  • M. Brian Traw

    (University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA)

  • Matthew Horton

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Petra Epple

    (University of North Carolina, Chapel Hill, North Carolina 27599, USA)

  • Christine Kuhns

    (The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK
    Albrecht von Haller Institute for Plant Sciences, Georg August University Göttingen)

  • Sridevi Sureshkumar

    (Max Planck Institute for Developmental Biology
    Present addresses: School of Biological Sciences, University of Queensland, St Lucia, Queensland 4072, Australia (S.B., S.S.); Lewis-Sigler Institute, Princeton University, Princeton, New Jersey 08544, USA (T.T.H.).)

  • Christopher Schwartz

    (Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    University of Wisconsin, Madison, Wisconsin 53706, USA)

  • Christa Lanz

    (Max Planck Institute for Developmental Biology)

  • Roosa A. E. Laitinen

    (Max Planck Institute for Developmental Biology)

  • Yu Huang

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

  • Joanne Chory

    (Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA)

  • Volker Lipka

    (The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK
    Albrecht von Haller Institute for Plant Sciences, Georg August University Göttingen)

  • Justin O. Borevitz

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Jeffery L. Dangl

    (University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Curriculum in Genetics and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA)

  • Joy Bergelson

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Magnus Nordborg

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
    Gregor Mendel Institute)

  • Detlef Weigel

    (Max Planck Institute for Developmental Biology)

Abstract

The genetics of plant variety Large-scale genome-wide association (GWA) studies have become an important tool in human genomics, mostly focused on disease but also on adaptive variations such as skin colour. The technique is now shown to be similarly useful in plants. Atwell et al. report a GWA study of over a hundred phenotypes in naturally occurring inbred lines of Arabidopsis thaliana. The results range from significant associations, usually for single genes, to more difficult-to-interpret findings that indicate confounding by complex genetics and population structure. The accompanying paper by Todesco et al. demonstrates the ability of this technique to detect major-effect gene loci. Using forward genetics and GWA analyses, they show that variation at a single locus (ACD6) in Arabidopsis underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains its persistence in natural populations throughout the world, despite it drastically reducing new leaf production.

Suggested Citation

  • Marco Todesco & Sureshkumar Balasubramanian & Tina T. Hu & M. Brian Traw & Matthew Horton & Petra Epple & Christine Kuhns & Sridevi Sureshkumar & Christopher Schwartz & Christa Lanz & Roosa A. E. Lait, 2010. "Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana," Nature, Nature, vol. 465(7298), pages 632-636, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7298:d:10.1038_nature09083
    DOI: 10.1038/nature09083
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    Cited by:

    1. Georgios Lagiotis & Panagiotis Madesis & Evangelia Stavridou, 2023. "Echoes of a Stressful Past: Abiotic Stress Memory in Crop Plants towards Enhanced Adaptation," Agriculture, MDPI, vol. 13(11), pages 1-30, November.

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