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Clues from cell metabolism

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  • William G. Kaelin

    (William G. Kaelin Jr is at the Howard Hughes Medical Institute, and at the Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. william_kaelin@dfci.harvard.edu;)

  • Craig B. Thompson

    (Craig B. Thompson is at the Abramson Cancer Center and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. craig@exchange.upenn.edu)

Abstract

Interest in the abnormal metabolism exhibited by cancer cells has been reawakened by the discovery of oncogenic mutations in metabolic enzymes, and by tools that monitor metabolism in living cells. Existing and emerging therapies aim to target this abnormal metabolism in various ways.

Suggested Citation

  • William G. Kaelin & Craig B. Thompson, 2010. "Clues from cell metabolism," Nature, Nature, vol. 465(7298), pages 562-564, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7298:d:10.1038_465562a
    DOI: 10.1038/465562a
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    Cited by:

    1. Luis Tobalina & Jon Pey & Alberto Rezola & Francisco J Planes, 2016. "Assessment of FBA Based Gene Essentiality Analysis in Cancer with a Fast Context-Specific Network Reconstruction Method," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-17, May.

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