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Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

Author

Listed:
  • Suphansa Sawamiphak

    (Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany)

  • Sascha Seidel

    (Institute of Neuropathology, Giessen University, Arndtstrasse 16, D-35392 Giessen, Germany)

  • Clara L. Essmann

    (Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany)

  • George A. Wilkinson

    (Developmental Vascular Biology Program, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA)

  • Mara E. Pitulescu

    (Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, Röntgenstrasse 20, D-48149 Münster, Germany)

  • Till Acker

    (Institute of Neuropathology, Giessen University, Arndtstrasse 16, D-35392 Giessen, Germany)

  • Amparo Acker-Palmer

    (Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany)

Abstract

Ephrin-B2/VEGF in angiogenesis control Ephrin-B ligands are well known as axon guidance molecules. Ephrin-B2 is also known to play a role in angiogenic remodelling. Two studies now show that signalling through ephrin-B2 controls vessel sprouting. Mechanistically, ephrin-B2 seems to function in part by regulating VEGFR internalization and signalling. The finding suggests that blocking ephrin-B2 signalling may be an alternative approach to blocking VEGFR function in angiogenesis.

Suggested Citation

  • Suphansa Sawamiphak & Sascha Seidel & Clara L. Essmann & George A. Wilkinson & Mara E. Pitulescu & Till Acker & Amparo Acker-Palmer, 2010. "Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis," Nature, Nature, vol. 465(7297), pages 487-491, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7297:d:10.1038_nature08995
    DOI: 10.1038/nature08995
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    Cited by:

    1. Shilpa Bhatia & Diemmy Nguyen & Laurel B. Darragh & Benjamin Van Court & Jaspreet Sharma & Michael W. Knitz & Miles Piper & Sanjana Bukkapatnam & Jacob Gadwa & Thomas E. Bickett & Shiv Bhuvane & Sophi, 2022. "EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Jonas Stewen & Kai Kruse & Anca T. Godoi-Filip & Zenia & Hyun-Woo Jeong & Susanne Adams & Frank Berkenfeld & Martin Stehling & Kristy Red-Horse & Ralf H. Adams & Mara E. Pitulescu, 2024. "Eph-ephrin signaling couples endothelial cell sorting and arterial specification," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    3. Ruth F. Dubin & Rajat Deo & Yue Ren & Jianqiao Wang & Zihe Zheng & Haochang Shou & Alan S. Go & Afshin Parsa & James P. Lash & Mahboob Rahman & Chi-yuan Hsu & Matthew R. Weir & Jing Chen & Amanda Ande, 2023. "Proteomics of CKD progression in the chronic renal insufficiency cohort," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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