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Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

Author

Listed:
  • Sebastian Lourido

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Joel Shuman

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Chao Zhang

    (Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94158, USA)

  • Kevan M. Shokat

    (Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94158, USA)

  • Raymond Hui

    (Structural Genomics Consortium, University Toronto, MaRS South Tower, Suite 732, 101 College Street, Toronto, Canada M5G 1L7)

  • L. David Sibley

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

Abstract

Kinase target in Toxoplasma gondii The protozoon Toxoplasma gondii, an opportunistic human pathogen, secretes organelles called micronemes, which play a key role in parasite motility, host-cell invasion and egress. This process is now shown to involve the T. gondii calcium dependent protein kinase 1 (TgCDPK1). The lack of this kinase family in mammalian hosts makes this protein an attractive target for drug design.

Suggested Citation

  • Sebastian Lourido & Joel Shuman & Chao Zhang & Kevan M. Shokat & Raymond Hui & L. David Sibley, 2010. "Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma," Nature, Nature, vol. 465(7296), pages 359-362, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7296:d:10.1038_nature09022
    DOI: 10.1038/nature09022
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    Cited by:

    1. Yaqiong Li & Zhipeng Niu & Jichao Yang & Xuke Yang & Yukun Chen & Yingying Li & Xiaohan Liang & Jingwen Zhang & Fuqiang Fan & Ping Wu & Chao Peng & Bang Shen, 2023. "Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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