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Designed biomaterials to mimic the mechanical properties of muscles

Author

Listed:
  • Shanshan Lv

    (University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada)

  • Daniel M. Dudek

    (University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada
    Present address: Department of Engineering Science and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.)

  • Yi Cao

    (University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada)

  • M. M. Balamurali

    (University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada)

  • John Gosline

    (University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada)

  • Hongbin Li

    (University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada)

Abstract

Muscle mimicry Shanshan Lv et al. have combined the well-characterized artificial elastomeric protein GB1 with resilin, a protein found in insects, to produce artificial proteins that mimic the molecular architecture of titin, the protein that largely governs the passive elastic properties of muscle. These new artificial proteins combine structured and unstructured domains and can be crosslinked into a solid. The resulting biomaterial is resilient at low strains, and extensible and tough at high strains, mimicking the passive properties of muscle, and making it potentially suitable for use in tissue engineering as a scaffold and matrix for artificial muscles. This is an example of tailoring the macroscopic properties of a material through engineering at the single molecule level.

Suggested Citation

  • Shanshan Lv & Daniel M. Dudek & Yi Cao & M. M. Balamurali & John Gosline & Hongbin Li, 2010. "Designed biomaterials to mimic the mechanical properties of muscles," Nature, Nature, vol. 465(7294), pages 69-73, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7294:d:10.1038_nature09024
    DOI: 10.1038/nature09024
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    Cited by:

    1. Xiaokang Zhang & Mengkui Cui & Shuoshuo Wang & Fei Han & Pingping Xu & Luyao Teng & Hang Zhao & Ping Wang & Guichu Yue & Yong Zhao & Guangfeng Liu & Ke Li & Jicong Zhang & Xiaoping Liang & Yingying Zh, 2022. "Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Serena Arnaboldi & Gerardo Salinas & Sabrina Bichon & Sebastien Gounel & Nicolas Mano & Alexander Kuhn, 2023. "Bi-enzymatic chemo-mechanical feedback loop for continuous self-sustained actuation of conducting polymers," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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