IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v465y2010i7294d10.1038_nature08958.html
   My bibliography  Save this article

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

Author

Listed:
  • Lyndsey Craven

    (Mitochondrial Research Group, Institute for Ageing and Health,)

  • Helen A. Tuppen

    (Mitochondrial Research Group, Institute for Ageing and Health,)

  • Gareth D. Greggains

    (Newcastle Fertility Centre, International Centre for Life,
    Institute for Ageing and Health, International Centre for Life,)

  • Stephen J. Harbottle

    (Newcastle Fertility Centre, International Centre for Life,)

  • Julie L. Murphy

    (Mitochondrial Research Group, Institute for Ageing and Health,)

  • Lynsey M. Cree

    (Mitochondrial Research Group, Institute for Ageing and Health,)

  • Alison P. Murdoch

    (Newcastle Fertility Centre, International Centre for Life,
    North East England Stem Cell Institute (NESCI), Bioscience Centre, International Centre for Life, Newcastle University, Newcastle upon Tyne NE1 4EP, UK)

  • Patrick F. Chinnery

    (Mitochondrial Research Group, Institute for Ageing and Health,)

  • Robert W. Taylor

    (Mitochondrial Research Group, Institute for Ageing and Health,)

  • Robert N. Lightowlers

    (Mitochondrial Research Group, Institute for Ageing and Health,)

  • Mary Herbert

    (Newcastle Fertility Centre, International Centre for Life,
    Institute for Ageing and Health, International Centre for Life,
    North East England Stem Cell Institute (NESCI), Bioscience Centre, International Centre for Life, Newcastle University, Newcastle upon Tyne NE1 4EP, UK)

  • Douglass M. Turnbull

    (Mitochondrial Research Group, Institute for Ageing and Health,
    Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    North East England Stem Cell Institute (NESCI), Bioscience Centre, International Centre for Life, Newcastle University, Newcastle upon Tyne NE1 4EP, UK)

Abstract

mtDNA replacement Mitochondrial DNA (mtDNA) mutations passed down from a mother to offspring are a common cause of genetic disease, including neurological, muscle and heart problems, deafness and type 2 diabetes. It was shown recently in non-human primates that nuclear transfer techniques can prevent their transmission. Now, that proof-of-principle work has been extended to human embryos (see News, http://go.nature.com/xqgWXf ). A multi-department team based at Newcastle University transferred pronuclei between human zygotes, and obtained onward development to the blastocyst stage in vitro. Carry-over of donor zygote mtDNA is minimal, so the technique could potentially prevent the transmission of mtDNA disease in humans.

Suggested Citation

  • Lyndsey Craven & Helen A. Tuppen & Gareth D. Greggains & Stephen J. Harbottle & Julie L. Murphy & Lynsey M. Cree & Alison P. Murdoch & Patrick F. Chinnery & Robert W. Taylor & Robert N. Lightowlers & , 2010. "Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease," Nature, Nature, vol. 465(7294), pages 82-85, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7294:d:10.1038_nature08958
    DOI: 10.1038/nature08958
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08958
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08958?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ana T Marcos & Jose M Navarro-Pando, 2018. "Could We Hack Women’s Biological Clock? A Mitochondrial Hypothesis," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 3(2), pages 33-35, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:465:y:2010:i:7294:d:10.1038_nature08958. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.