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Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

Author

Listed:
  • Sergio E. Baranzini

    (University of California at San Francisco, San Francisco, California 94143, USA)

  • Joann Mudge

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Jennifer C. van Velkinburgh

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Pouya Khankhanian

    (University of California at San Francisco, San Francisco, California 94143, USA)

  • Irina Khrebtukova

    (Illumina Inc., Hayward, California 94545, USA)

  • Neil A. Miller

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Lu Zhang

    (Illumina Inc., Hayward, California 94545, USA)

  • Andrew D. Farmer

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Callum J. Bell

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Ryan W. Kim

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Gregory D. May

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Jimmy E. Woodward

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Stacy J. Caillier

    (University of California at San Francisco, San Francisco, California 94143, USA)

  • Joseph P. McElroy

    (University of California at San Francisco, San Francisco, California 94143, USA)

  • Refujia Gomez

    (University of California at San Francisco, San Francisco, California 94143, USA)

  • Marcelo J. Pando

    (Stanford Medical School Blood Center, Palo Alto, California 94303, USA)

  • Leonda E. Clendenen

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Elena E. Ganusova

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Faye D. Schilkey

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Thiruvarangan Ramaraj

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

  • Omar A. Khan

    (Wayne State Medical School, Detroit, Michigan 48201, USA)

  • Jim J. Huntley

    (Illumina Inc., Hayward, California 94545, USA)

  • Shujun Luo

    (Illumina Inc., Hayward, California 94545, USA)

  • Pui-yan Kwok

    (Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Institute for Human Genetics, University of California at San Francisco, San Francisco, California 94143, USA)

  • Thomas D. Wu

    (Genentech Inc., South San Francisco, California 94080, USA)

  • Gary P. Schroth

    (Illumina Inc., Hayward, California 94545, USA)

  • Jorge R. Oksenberg

    (University of California at San Francisco, San Francisco, California 94143, USA
    Institute for Human Genetics, University of California at San Francisco, San Francisco, California 94143, USA)

  • Stephen L. Hauser

    (University of California at San Francisco, San Francisco, California 94143, USA
    Institute for Human Genetics, University of California at San Francisco, San Francisco, California 94143, USA)

  • Stephen F. Kingsmore

    (National Center for Genome Resources, Santa Fe, New Mexico 87505, USA)

Abstract

The genomics of multiple sclerosis Identical (or more correctly 'monozygotic') twins are widely used to study the contributions of genetics and environment to human disease. A study that focused on three pairs of monozygotic twins, in which one twin had multiple sclerosis and the other did not, has brought the latest techniques of genome sequencing and analysis to this field, and incidentally published the first female human genome sequences. Full sequences were determined for one pair of twins, and for these and the other two pairs the mRNA transcriptome and epigenome sequences of CD4+ lymphocytes were determined. The striking result is that no genetic, epigenetic or transcriptome differences were found that explained why one twin had the disease and the other did not. Digging deeper into the data, eQTL (expression quantitative trait locus) mapping revealed tantalizing differences within twin pairs that merit closer examination. And some possible causes can be ruled out. Future work might usefully concentrate on studies of other cell types and epigenetic modifications.

Suggested Citation

  • Sergio E. Baranzini & Joann Mudge & Jennifer C. van Velkinburgh & Pouya Khankhanian & Irina Khrebtukova & Neil A. Miller & Lu Zhang & Andrew D. Farmer & Callum J. Bell & Ryan W. Kim & Gregory D. May &, 2010. "Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis," Nature, Nature, vol. 464(7293), pages 1351-1356, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7293:d:10.1038_nature08990
    DOI: 10.1038/nature08990
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    Cited by:

    1. Cristina Menni & Walter E. Lowell & Joan Bentzen & Roberto Bergamaschi & Filippo Martinelli Boneschi & Vittorio Martinelli & Luisa Bernardinelli & Egon Stenager & George E. Davis & Luisa Foco, 2012. "Short and Long Term Variation in Ultraviolet Radiation and Multiple Sclerosis," IJERPH, MDPI, vol. 9(3), pages 1-13, February.

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