IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v464y2010i7291d10.1038_nature08895.html
   My bibliography  Save this article

Functional genomic screen for modulators of ciliogenesis and cilium length

Author

Listed:
  • Joon Kim

    (Institute for Genomic Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA)

  • Ji Eun Lee

    (Institute for Genomic Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA)

  • Susanne Heynen-Genel

    (High Content Screening and Functional Genomics Core, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA)

  • Eigo Suyama

    (High Content Screening and Functional Genomics Core, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA)

  • Keiichiro Ono

    (University of California San Diego, La Jolla, California 92093, USA)

  • KiYoung Lee

    (University of California San Diego, La Jolla, California 92093, USA
    Ajou University School of Medicine)

  • Trey Ideker

    (University of California San Diego, La Jolla, California 92093, USA)

  • Pedro Aza-Blanc

    (High Content Screening and Functional Genomics Core, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA)

  • Joseph G. Gleeson

    (Institute for Genomic Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA)

Abstract

Screening for ciliogenesis genes Primary cilia are tiny hair-like structures expressed on the surface of eukaryotic cells. They participate in a wide range of biological processes such as sensing the extracellular environment to regulating numerous signalling pathways during development. Ciliary dysfunction has been linked to a group of human disorders known as ciliopathies. This study presents a functional genomic screen using RNA interference (RNAi) to identify human genes involved in control of ciliogenesis. Several positive and negative modulators of ciliogenesis with broad ranging functions were identified. Development of specific inhibitors that target key proteins may provide novel strategies to treat ciliopathies.

Suggested Citation

  • Joon Kim & Ji Eun Lee & Susanne Heynen-Genel & Eigo Suyama & Keiichiro Ono & KiYoung Lee & Trey Ideker & Pedro Aza-Blanc & Joseph G. Gleeson, 2010. "Functional genomic screen for modulators of ciliogenesis and cilium length," Nature, Nature, vol. 464(7291), pages 1048-1051, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08895
    DOI: 10.1038/nature08895
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08895
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08895?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xueguang Zhang & Lingbo Wang & Yongyi Ma & Yan Wang & Hongqian Liu & Mohan Liu & Lang Qin & Jinghong Li & Chuan Jiang & Xiaojian Zhang & Xudong Shan & Yuliang Liu & Jinsong Li & Yaqian Li & Rui Zheng , 2022. "CEP128 is involved in spermatogenesis in humans and mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Muqing Cao & Xiaoxiao Zou & Chaoyi Li & Zaisheng Lin & Ni Wang & Zhongju Zou & Youqiong Ye & Joachim Seemann & Beth Levine & Zaiming Tang & Qing Zhong, 2023. "An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08895. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.