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APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

Author

Listed:
  • Yutaka Shimomura

    (Department of Dermatology,)

  • Dritan Agalliu

    (Stanford University, Stanford, California 94305, USA)

  • Alin Vonica

    (The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, New York 10065, USA)

  • Victor Luria

    (Department of Dermatology,
    Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC15 204A, New York, New York 10032, USA)

  • Muhammad Wajid

    (Department of Dermatology,)

  • Alessandra Baumer

    (Institute of Medical Genetics, University of Zurich)

  • Serena Belli

    (Struttura Semplice Genetica Medica APSS)

  • Lynn Petukhova

    (Department of Dermatology,)

  • Albert Schinzel

    (Institute of Medical Genetics, University of Zurich)

  • Ali H. Brivanlou

    (The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, New York 10065, USA)

  • Ben A. Barres

    (Stanford University, Stanford, California 94305, USA)

  • Angela M. Christiano

    (Department of Dermatology,
    Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC15 204A, New York, New York 10032, USA)

Abstract

The routes of hair growth Hair follicle miniaturization is a degenerative process that reduces the dimensions of the epithelial and mesenchymal cell compartments, converting thick hair to fine, downy hair. It is most commonly observed in androgenetic alopecia, but is also characteristic of a rare form of hair loss known as hereditary hypotrichosis simplex (HHS). The gene involved in HHS has now been identified by genetic linkage analysis in affected families as APCDD1, which encodes a membrane-bound glycoprotein abundantly expressed in human hair follicles. Functional studies show that APCDD1 inhibits Wnt signalling, and is thus a potentially important component of signal transduction pathways in the hair follicle.

Suggested Citation

  • Yutaka Shimomura & Dritan Agalliu & Alin Vonica & Victor Luria & Muhammad Wajid & Alessandra Baumer & Serena Belli & Lynn Petukhova & Albert Schinzel & Ali H. Brivanlou & Ben A. Barres & Angela M. Chr, 2010. "APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex," Nature, Nature, vol. 464(7291), pages 1043-1047, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08875
    DOI: 10.1038/nature08875
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    Cited by:

    1. Wenmin Sun & Dan Xiong & Jiamin Ouyang & Xueshan Xiao & Yi Jiang & Yingwei Wang & Shiqiang Li & Ziying Xie & Junwen Wang & Zhonghui Tang & Qingjiong Zhang, 2024. "Altered chromatin topologies caused by balanced chromosomal translocation lead to central iris hypoplasia," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Agnes Forsthuber & Bertram Aschenbrenner & Ana Korosec & Tina Jacob & Karl Annusver & Natalia Krajic & Daria Kholodniuk & Sophie Frech & Shaohua Zhu & Kim Purkhauser & Katharina Lipp & Franziska Werne, 2024. "Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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