IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v464y2010i7291d10.1038_nature08875.html
   My bibliography  Save this article

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

Author

Listed:
  • Yutaka Shimomura

    (Department of Dermatology,)

  • Dritan Agalliu

    (Stanford University, Stanford, California 94305, USA)

  • Alin Vonica

    (The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, New York 10065, USA)

  • Victor Luria

    (Department of Dermatology,
    Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC15 204A, New York, New York 10032, USA)

  • Muhammad Wajid

    (Department of Dermatology,)

  • Alessandra Baumer

    (Institute of Medical Genetics, University of Zurich)

  • Serena Belli

    (Struttura Semplice Genetica Medica APSS)

  • Lynn Petukhova

    (Department of Dermatology,)

  • Albert Schinzel

    (Institute of Medical Genetics, University of Zurich)

  • Ali H. Brivanlou

    (The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, New York 10065, USA)

  • Ben A. Barres

    (Stanford University, Stanford, California 94305, USA)

  • Angela M. Christiano

    (Department of Dermatology,
    Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC15 204A, New York, New York 10032, USA)

Abstract

The routes of hair growth Hair follicle miniaturization is a degenerative process that reduces the dimensions of the epithelial and mesenchymal cell compartments, converting thick hair to fine, downy hair. It is most commonly observed in androgenetic alopecia, but is also characteristic of a rare form of hair loss known as hereditary hypotrichosis simplex (HHS). The gene involved in HHS has now been identified by genetic linkage analysis in affected families as APCDD1, which encodes a membrane-bound glycoprotein abundantly expressed in human hair follicles. Functional studies show that APCDD1 inhibits Wnt signalling, and is thus a potentially important component of signal transduction pathways in the hair follicle.

Suggested Citation

  • Yutaka Shimomura & Dritan Agalliu & Alin Vonica & Victor Luria & Muhammad Wajid & Alessandra Baumer & Serena Belli & Lynn Petukhova & Albert Schinzel & Ali H. Brivanlou & Ben A. Barres & Angela M. Chr, 2010. "APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex," Nature, Nature, vol. 464(7291), pages 1043-1047, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08875
    DOI: 10.1038/nature08875
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08875
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08875?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wenmin Sun & Dan Xiong & Jiamin Ouyang & Xueshan Xiao & Yi Jiang & Yingwei Wang & Shiqiang Li & Ziying Xie & Junwen Wang & Zhonghui Tang & Qingjiong Zhang, 2024. "Altered chromatin topologies caused by balanced chromosomal translocation lead to central iris hypoplasia," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08875. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.