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The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

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  • Jun Huang

    (Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Present addresses: Department of Microbiology and Immunology and The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA (J.H.); Department of Bioengineering, Stanford University, Stanford, California 94305, USA (N.J.).)

  • Veronika I. Zarnitsyna

    (Georgia Institute of Technology, Atlanta, Georgia 30332, USA)

  • Baoyu Liu

    (Georgia Institute of Technology, Atlanta, Georgia 30332, USA)

  • Lindsay J. Edwards

    (Emory University School of Medicine, Atlanta, Georgia 30322, USA)

  • Ning Jiang

    (Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Present addresses: Department of Microbiology and Immunology and The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA (J.H.); Department of Bioengineering, Stanford University, Stanford, California 94305, USA (N.J.).)

  • Brian D. Evavold

    (Emory University School of Medicine, Atlanta, Georgia 30322, USA)

  • Cheng Zhu

    (Georgia Institute of Technology, Atlanta, Georgia 30332, USA)

Abstract

Two-dimensional kinetics of TCR recognition Studies of the interaction between T-cell receptors (TCRs) and the peptide-major histocompatibility complex (pMHC), which is central to discrimination between pathogens and self antigens, have generally involved 'three-dimensional' analysis, with one of the interacting partners in solution. The resulting kinetic data have not adequately recorded the T-cell response. In reality TCR–pMHC interactions occur in two dimensions, at points of contact between two cells. Here Huang et al. show that two-dimensional TCR–pMHC-binding parameters accurately match the extent of the T-cell response.

Suggested Citation

  • Jun Huang & Veronika I. Zarnitsyna & Baoyu Liu & Lindsay J. Edwards & Ning Jiang & Brian D. Evavold & Cheng Zhu, 2010. "The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness," Nature, Nature, vol. 464(7290), pages 932-936, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7290:d:10.1038_nature08944
    DOI: 10.1038/nature08944
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    Cited by:

    1. Yueyang Sun & Lu Yan & Jiajia Sun & Mingshu Xiao & Wei Lai & Guangqi Song & Li Li & Chunhai Fan & Hao Pei, 2022. "Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8+ T cell detection," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Renske M A Vroomans & Athanasius F M Marée & Rob J de Boer & Joost B Beltman, 2012. "Chemotactic Migration of T Cells towards Dendritic Cells Promotes the Detection of Rare Antigens," PLOS Computational Biology, Public Library of Science, vol. 8(11), pages 1-13, November.
    3. Marion C Lanteri & Zhanna Kaidarova & Trevor Peterson & Steven Cate & Brian Custer & Shiquan Wu & Maria Agapova & Jacqueline P Law & Thomas Bielawny & Frank Plummer & Leslie H Tobler & Mark Loeb & Mic, 2011. "Association between HLA Class I and Class II Alleles and the Outcome of West Nile Virus Infection: An Exploratory Study," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-10, August.
    4. Hyun-Kyu Choi & Peiwen Cong & Chenghao Ge & Aswin Natarajan & Baoyu Liu & Yong Zhang & Kaitao Li & Muaz Nik Rushdi & Wei Chen & Jizhong Lou & Michelle Krogsgaard & Cheng Zhu, 2023. "Catch bond models may explain how force amplifies TCR signaling and antigen discrimination," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Muaz Nik Rushdi & Victor Pan & Kaitao Li & Hyun-Kyu Choi & Stefano Travaglino & Jinsung Hong & Fletcher Griffitts & Pragati Agnihotri & Roy A. Mariuzza & Yonggang Ke & Cheng Zhu, 2022. "Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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