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Double Holliday junctions are intermediates of DNA break repair

Author

Listed:
  • Malgorzata Bzymek

    (Department of Microbiology,)

  • Nathaniel H. Thayer

    (Molecular and Cellular Biology PhD Program, University of Washington, Seattle, Washington 98195-7275, USA)

  • Steve D. Oh

    (University of California, San Francisco, California 94143-0511, USA)

  • Nancy Kleckner

    (Harvard University, Cambridge, Massachusetts 02138, USA)

  • Neil Hunter

    (Department of Microbiology,
    and Cell Biology & Human Anatomy, University of California Davis, Davis, California 95616, USA)

Abstract

DNA repair intermediates In meiotic cells, it is well established that the paired homologues are joined by a set of crossovers known as a double Holliday junction (DHJ). Whether DHJs form during mitotic recombination has been unclear, since mitotic cells possess alternative repair pathways that would not require DHJ formation. Bzymek et al. now demonstrate that mitotic and meiotic cells form similar DHJs, but that the levels in mitotic cells are approximately 10-fold lower, and show a preference for joints between sister chromatids rather than homologues. Consequently in mitotic cells non-crossover outcomes are favoured.

Suggested Citation

  • Malgorzata Bzymek & Nathaniel H. Thayer & Steve D. Oh & Nancy Kleckner & Neil Hunter, 2010. "Double Holliday junctions are intermediates of DNA break repair," Nature, Nature, vol. 464(7290), pages 937-941, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7290:d:10.1038_nature08868
    DOI: 10.1038/nature08868
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    Cited by:

    1. Chinnu Rose Joseph & Sabrina Dusi & Michele Giannattasio & Dana Branzei, 2022. "Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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