IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v464y2010i7289d10.1038_nature08853.html
   My bibliography  Save this article

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

Author

Listed:
  • Jason M. Kinchen

    (Center for Cell Clearance and,
    University of Virginia, Charlottesville, Virginia 22908, USA)

  • Kodi S. Ravichandran

    (Center for Cell Clearance and,
    Beirne Carter Center for Immunology Research,
    University of Virginia, Charlottesville, Virginia 22908, USA)

Abstract

Apoptosis: dealing with the corpse Apoptotic cells are removed from tissues through recognition and engulfment by phagocytes. While recent studies have identified receptors that mediate interactions between apoptotic cells and phagocytes, the molecular mechanisms underlying the degradation of apoptotic cells following engulfment remain unclear. Here, Jason Kinchen and Kodi Ravichandran identify two evolutionarily conserved genes that are required for the processing of ingested apoptotic cells in Caenorhabditis elegans and mammalian cells. These genes are required for phagosome maturation through a mechanism involving Rab conversion. As poor engulfment of apoptotic cells is associated with some diseases, understanding this process could lead to new treatments.

Suggested Citation

  • Jason M. Kinchen & Kodi S. Ravichandran, 2010. "Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells," Nature, Nature, vol. 464(7289), pages 778-782, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7289:d:10.1038_nature08853
    DOI: 10.1038/nature08853
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08853
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08853?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hui Tu & Zhimeng Wang & Ye Yuan & Xilin Miao & Dong Li & Hu Guo & Yihong Yang & Huaqing Cai, 2022. "The PripA-TbcrA complex-centered Rab GAP cascade facilitates macropinosome maturation in Dictyostelium," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:464:y:2010:i:7289:d:10.1038_nature08853. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.