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Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

Author

Listed:
  • Chris Jopling

    (Center of Regenerative Medicine in Barcelona,)

  • Eduard Sleep

    (Center of Regenerative Medicine in Barcelona,
    Networking Center of Biomedical Research in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Dr Aiguader Street 88, 08003 Barcelona, Spain
    Present addresses: Control of Stem Cell Potency group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 15, 08028 Barcelona, Spain (E.S., A.R.); Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), Dr Aiguader Street 88, 08003 Barcelona, Spain (M.R.).)

  • Marina Raya

    (Center of Regenerative Medicine in Barcelona,
    Present addresses: Control of Stem Cell Potency group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 15, 08028 Barcelona, Spain (E.S., A.R.); Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), Dr Aiguader Street 88, 08003 Barcelona, Spain (M.R.).)

  • Mercè Martí

    (Center of Regenerative Medicine in Barcelona,)

  • Angel Raya

    (Center of Regenerative Medicine in Barcelona,
    Networking Center of Biomedical Research in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Dr Aiguader Street 88, 08003 Barcelona, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluis Companys 23, 08010 Barcelona, Spain
    Present addresses: Control of Stem Cell Potency group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 15, 08028 Barcelona, Spain (E.S., A.R.); Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), Dr Aiguader Street 88, 08003 Barcelona, Spain (M.R.).)

  • Juan Carlos Izpisúa Belmonte

    (Center of Regenerative Medicine in Barcelona,
    Networking Center of Biomedical Research in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Dr Aiguader Street 88, 08003 Barcelona, Spain
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Cardiac regeneration Zebrafish are able to efficiently regenerate lost cardiac muscle, and is used as a model to understand why natural heart regeneration is blocked in mammals. Two groups reporting in the issue of Nature used genetic fate-mapping approaches to identify which population of cardiomyocytes contribute prominently to cardiac muscle regeneration after an injury approximating myocardial infarction. They show that cardiac muscle regenerates through activation and expansion of existing cardiomyocytes, and does not involve activation of a stem cell population.

Suggested Citation

  • Chris Jopling & Eduard Sleep & Marina Raya & Mercè Martí & Angel Raya & Juan Carlos Izpisúa Belmonte, 2010. "Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation," Nature, Nature, vol. 464(7288), pages 606-609, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7288:d:10.1038_nature08899
    DOI: 10.1038/nature08899
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    Cited by:

    1. Yu Xia & Sierra Duca & Björn Perder & Friederike Dündar & Paul Zumbo & Miaoyan Qiu & Jun Yao & Yingxi Cao & Michael R. M. Harrison & Lior Zangi & Doron Betel & Jingli Cao, 2022. "Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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