IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v464y2010i7288d10.1038_nature08804.html
   My bibliography  Save this article

Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

Author

Listed:
  • Kazu Kikuchi

    (Department of Cell Biology,
    Howard Hughes Medical Institute,)

  • Jennifer E. Holdway

    (Department of Cell Biology,
    Howard Hughes Medical Institute,)

  • Andreas A. Werdich

    (Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA)

  • Ryan M. Anderson

    (University of California San Francisco, San Francisco, California 94158, USA)

  • Yi Fang

    (Department of Cell Biology,
    Howard Hughes Medical Institute,)

  • Gregory F. Egnaczyk

    (Department of Cell Biology,
    Howard Hughes Medical Institute,
    Duke University Medical Center, Durham, North Carolina 27710, USA)

  • Todd Evans

    (Weill Cornell Medical College, Cornell University, New York, New York 10021, USA)

  • Calum A. MacRae

    (Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA)

  • Didier Y. R. Stainier

    (University of California San Francisco, San Francisco, California 94158, USA)

  • Kenneth D. Poss

    (Department of Cell Biology,
    Howard Hughes Medical Institute,)

Abstract

Cardiac regeneration Zebrafish are able to efficiently regenerate lost cardiac muscle, and is used as a model to understand why natural heart regeneration is blocked in mammals. Two groups reporting in the issue of Nature used genetic fate-mapping approaches to identify which population of cardiomyocytes contribute prominently to cardiac muscle regeneration after an injury approximating myocardial infarction. They show that cardiac muscle regenerates through activation and expansion of existing cardiomyocytes, and does not involve activation of a stem cell population.

Suggested Citation

  • Kazu Kikuchi & Jennifer E. Holdway & Andreas A. Werdich & Ryan M. Anderson & Yi Fang & Gregory F. Egnaczyk & Todd Evans & Calum A. MacRae & Didier Y. R. Stainier & Kenneth D. Poss, 2010. "Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes," Nature, Nature, vol. 464(7288), pages 601-605, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7288:d:10.1038_nature08804
    DOI: 10.1038/nature08804
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08804
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08804?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Carmen Sena-Tomás & Angelika G. Aleman & Caitlin Ford & Akriti Varshney & Di Yao & Jamie K. Harrington & Leonor Saúde & Mirana Ramialison & Kimara L. Targoff, 2022. "Activation of Nkx2.5 transcriptional program is required for adult myocardial repair," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:464:y:2010:i:7288:d:10.1038_nature08804. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.