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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

Author

Listed:
  • Diego Pasini

    (Biotech Research and Innovation Centre (BRIC),
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    Present address: European Institute of Oncology, Department of Experimental Oncology, Via Adamello 16, 20141 Milan, Italy.)

  • Paul A. C. Cloos

    (Biotech Research and Innovation Centre (BRIC),
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark)

  • Julian Walfridsson

    (Biotech Research and Innovation Centre (BRIC),
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark)

  • Linda Olsson

    (Biotech Research and Innovation Centre (BRIC),
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark)

  • John-Paul Bukowski

    (Biotech Research and Innovation Centre (BRIC),
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark)

  • Jens V. Johansen

    (Biotech Research and Innovation Centre (BRIC),)

  • Mads Bak

    (Wilhelm Johannsen Centre For Functional Genome Research, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark)

  • Niels Tommerup

    (Wilhelm Johannsen Centre For Functional Genome Research, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark)

  • Juri Rappsilber

    (Wellcome Trust Centre for Cell Biology, University of Edinburgh)

  • Kristian Helin

    (Biotech Research and Innovation Centre (BRIC),
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark)

Abstract

Role for JARID2 in embryonic stem cells Polycomb proteins have a key role in regulating the expression of genes essential for development, differentiation and maintenance of cell fates. Here, Polycomb repressive complex 2 (PRC2) is shown to form a complex with JARID2, a Jumonji domain protein. JARID2 is required for the binding of Polycomb proteins to target genes in embryonic stem cells as well as for the proper differentiation of embryonic stem cells and normal development.

Suggested Citation

  • Diego Pasini & Paul A. C. Cloos & Julian Walfridsson & Linda Olsson & John-Paul Bukowski & Jens V. Johansen & Mads Bak & Niels Tommerup & Juri Rappsilber & Kristian Helin, 2010. "JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells," Nature, Nature, vol. 464(7286), pages 306-310, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7286:d:10.1038_nature08788
    DOI: 10.1038/nature08788
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    Cited by:

    1. Suganth Suppiah & Sheila Mansouri & Yasin Mamatjan & Jeffrey C. Liu & Minu M. Bhunia & Vikas Patil & Prisni Rath & Bharati Mehani & Pardeep Heir & Severa Bunda & German L. Velez-Reyes & Olivia Singh &, 2023. "Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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