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The cells and peripheral representation of sodium taste in mice

Author

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  • Jayaram Chandrashekar

    (University of California at San Diego, La Jolla, California 92093-0649, USA
    Present addresses: Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA (J.C.); Departments of Biochemistry and Molecular Biophysics and of Neuroscience, Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA (Y.O., D.A.Y., C.S.Z.).)

  • Christina Kuhn

    (National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Yuki Oka

    (University of California at San Diego, La Jolla, California 92093-0649, USA
    Present addresses: Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA (J.C.); Departments of Biochemistry and Molecular Biophysics and of Neuroscience, Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA (Y.O., D.A.Y., C.S.Z.).)

  • David A. Yarmolinsky

    (University of California at San Diego, La Jolla, California 92093-0649, USA
    Present addresses: Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA (J.C.); Departments of Biochemistry and Molecular Biophysics and of Neuroscience, Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA (Y.O., D.A.Y., C.S.Z.).)

  • Edith Hummler

    (Faculty of Biology and Medicine, University of Lausanne)

  • Nicholas J. P. Ryba

    (National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Charles S. Zuker

    (University of California at San Diego, La Jolla, California 92093-0649, USA
    Present addresses: Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA (J.C.); Departments of Biochemistry and Molecular Biophysics and of Neuroscience, Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA (Y.O., D.A.Y., C.S.Z.).)

Abstract

Salt to taste Mammals are repelled by large concentrations of salts but attracted to low concentrations of sodium. In mice, the latter behaviour can be blocked by the ion-channel inhibitor amiloride. Now mice genetically engineered to lack the drug's target sodium channel, ENaC, in taste receptor neurons have been found to lack both salt sensing and sodium taste responses. Thus sodium sensing, like the four other taste modalities (sweet, sour, bitter and umami), is mediated by dedicated taste-receptor cells. Though because sodium sensing is amiloride-insensitive in primates, how this relates to our ability to taste salt remains unclear.

Suggested Citation

  • Jayaram Chandrashekar & Christina Kuhn & Yuki Oka & David A. Yarmolinsky & Edith Hummler & Nicholas J. P. Ryba & Charles S. Zuker, 2010. "The cells and peripheral representation of sodium taste in mice," Nature, Nature, vol. 464(7286), pages 297-301, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7286:d:10.1038_nature08783
    DOI: 10.1038/nature08783
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    Cited by:

    1. Shobha Mummalaneni & Jie Qian & Tam-Hao T Phan & Mee-Ra Rhyu & Gerard L Heck & John A DeSimone & Vijay Lyall, 2014. "Effect of ENaC Modulators on Rat Neural Responses to NaCl," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-18, May.
    2. Ziyu Liang & Courtney E. Wilson & Bochuan Teng & Sue C. Kinnamon & Emily R. Liman, 2023. "The proton channel OTOP1 is a sensor for the taste of ammonium chloride," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Ashkan A. Shahbandi & Ezen Choo & Robin Dando, 2018. "Receptor Regulation in Taste: Can Diet Influence How We Perceive Foods?," J, MDPI, vol. 1(1), pages 1-10, October.

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