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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

Author

Listed:
  • Christian Popp

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, and Centre for Trophoblast Research, University of Cambridge)

  • Wendy Dean

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, and Centre for Trophoblast Research, University of Cambridge)

  • Suhua Feng

    (University of California at Los Angeles, Los Angeles, California 90095, USA)

  • Shawn J. Cokus

    (University of California at Los Angeles, Los Angeles, California 90095, USA)

  • Simon Andrews

    (Bioinformatics Group, The Babraham Institute)

  • Matteo Pellegrini

    (University of California at Los Angeles, Los Angeles, California 90095, USA)

  • Steven E. Jacobsen

    (University of California at Los Angeles, Los Angeles, California 90095, USA
    Howard Hughes Medical Institute, University of California at Los Angeles, Los Angeles, California 90095, USA)

  • Wolf Reik

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, and Centre for Trophoblast Research, University of Cambridge)

Abstract

AID-dependent DNA methylation in primordial germ cells Epigenetic reprogramming including demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, but the extent of this reprogramming and its molecular mechanisms are poorly understood. Here, DNA methylation profiling in PGCs reveals a genome-wide erasure of methylation, with female PGCs being less methylated than male ones. A deficiency of the cytidine deaminase AID interferes with the genome-wide erasure of DNA methylation, suggesting that AID has a critical function in epigenetic reprogramming.

Suggested Citation

  • Christian Popp & Wendy Dean & Suhua Feng & Shawn J. Cokus & Simon Andrews & Matteo Pellegrini & Steven E. Jacobsen & Wolf Reik, 2010. "Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency," Nature, Nature, vol. 463(7284), pages 1101-1105, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7284:d:10.1038_nature08829
    DOI: 10.1038/nature08829
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    Cited by:

    1. Allegra Angeloni & Skye Fissette & Deniz Kaya & Jillian M. Hammond & Hasindu Gamaarachchi & Ira W. Deveson & Robert J. Klose & Weiming Li & Xiaotian Zhang & Ozren Bogdanovic, 2024. "Extensive DNA methylome rearrangement during early lamprey embryogenesis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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