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Complete Khoisan and Bantu genomes from southern Africa

Author

Listed:
  • Stephan C. Schuster

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Webb Miller

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Aakrosh Ratan

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Lynn P. Tomsho

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Belinda Giardine

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Lindsay R. Kasson

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Robert S. Harris

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Desiree C. Petersen

    (Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, C25 Lowy Cancer Research Centre University of New South Wales, High Street, New South Wales 2031, Australia)

  • Fangqing Zhao

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Ji Qi

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Can Alkan

    (University of Washington, and Howard Hughes Medical Institute, Foege S-413-C, Box 355065, Seattle, Washington 98195-5065, USA)

  • Jeffrey M. Kidd

    (University of Washington, and Howard Hughes Medical Institute, Foege S-413-C, Box 355065, Seattle, Washington 98195-5065, USA)

  • Yazhou Sun

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Daniela I. Drautz

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Pascal Bouffard

    (Roche Diagnostics Corporation, Indianapolis, Indiana 46250-0414, USA)

  • Donna M. Muzny

    (The Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Jeffrey G. Reid

    (The Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Lynne V. Nazareth

    (The Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Qingyu Wang

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Richard Burhans

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Cathy Riemer

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Nicola E. Wittekindt

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Priya Moorjani

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Elizabeth A. Tindall

    (Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, C25 Lowy Cancer Research Centre University of New South Wales, High Street, New South Wales 2031, Australia
    University of New South Wales, Randwick, New South Wales 2031, Australia)

  • Charles G. Danko

    (101 Biotechnology Building, Cornell University, Ithaca, New York 14853, USA)

  • Wee Siang Teo

    (Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, C25 Lowy Cancer Research Centre University of New South Wales, High Street, New South Wales 2031, Australia
    University of New South Wales, Randwick, New South Wales 2031, Australia)

  • Anne M. Buboltz

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Zhenhai Zhang

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Qianyi Ma

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Arno Oosthuysen

    (PO Box 1899, Tsumeb, Namibia)

  • Abraham W. Steenkamp

    (PO Box 180, Arnos, Namibia)

  • Hermann Oostuisen

    (PO Box 1077, Grootfontein, Namibia)

  • Philippus Venter

    (University of Limpopo, Turfloop Campus, P/Bag X1106, 0727 Sovenga, South Africa)

  • John Gajewski

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Yu Zhang

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • B. Franklin Pugh

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Kateryna D. Makova

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Anton Nekrutenko

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Elaine R. Mardis

    (Washington University in St Louis, School of Medicine, The Genome Center, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Nick Patterson

    (Broad Institute of MIT (Massachusetts Institute of Technology) and Harvard University, Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Tom H. Pringle

    (Sperling Foundation, Eugene, Oregon 97405, USA)

  • Francesca Chiaromonte

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • James C. Mullikin

    (National Human Genome Research Institute, National Institutes of Health, 5625 Fishers Lane, Room 5N-01Q, MSC 9400, Rockville, Maryland 20892-9400, USA)

  • Evan E. Eichler

    (University of Washington, and Howard Hughes Medical Institute, Foege S-413-C, Box 355065, Seattle, Washington 98195-5065, USA)

  • Ross C. Hardison

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Richard A. Gibbs

    (The Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Timothy T. Harkins

    (Roche Diagnostics Corporation, Indianapolis, Indiana 46250-0414, USA)

  • Vanessa M. Hayes

    (Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, C25 Lowy Cancer Research Centre University of New South Wales, High Street, New South Wales 2031, Australia
    University of New South Wales, Randwick, New South Wales 2031, Australia)

Abstract

Southern African genomes The complete genome sequences of an indigenous hunter-gatherer from Namibia's Kalahari Desert and of a Bantu from South Africa are presented in this issue, together with protein-coding regions from three other hunter-gatherer groups from the Kalahari. Analysis of genetic variance in what is probably the oldest known modern human lineage will contribute to understanding human diversity, and facilitate the inclusion of southern Africans in medical genomics research projects. Initial observations from the data include the fact that the Bushmen seem more different from each other, in terms of nucleotide substitutions, than typical Asians and Europeans. More speculatively, variants between these genomes and the existing data sets may point to genetic adaptations for an agricultural lifestyle.

Suggested Citation

  • Stephan C. Schuster & Webb Miller & Aakrosh Ratan & Lynn P. Tomsho & Belinda Giardine & Lindsay R. Kasson & Robert S. Harris & Desiree C. Petersen & Fangqing Zhao & Ji Qi & Can Alkan & Jeffrey M. Kidd, 2010. "Complete Khoisan and Bantu genomes from southern Africa," Nature, Nature, vol. 463(7283), pages 943-947, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7283:d:10.1038_nature08795
    DOI: 10.1038/nature08795
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    Cited by:

    1. Xiaoru Xie & Liman Huang & Jun (Justin) Li & Hong Zhu, 2020. "Generational Differences in Perceptions of Food Health/Risk and Attitudes toward Organic Food and Game Meat: The Case of the COVID-19 Crisis in China," IJERPH, MDPI, vol. 17(9), pages 1-17, April.
    2. Ruha Benjamin, 2015. "The Emperor’s New Genes," The ANNALS of the American Academy of Political and Social Science, , vol. 661(1), pages 130-142, September.

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