IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v463y2010i7283d10.1038_nature08795.html
   My bibliography  Save this article

Complete Khoisan and Bantu genomes from southern Africa

Author

Listed:
  • Stephan C. Schuster

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Webb Miller

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Aakrosh Ratan

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Lynn P. Tomsho

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Belinda Giardine

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Lindsay R. Kasson

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Robert S. Harris

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Desiree C. Petersen

    (Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, C25 Lowy Cancer Research Centre University of New South Wales, High Street, New South Wales 2031, Australia)

  • Fangqing Zhao

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Ji Qi

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Can Alkan

    (University of Washington, and Howard Hughes Medical Institute, Foege S-413-C, Box 355065, Seattle, Washington 98195-5065, USA)

  • Jeffrey M. Kidd

    (University of Washington, and Howard Hughes Medical Institute, Foege S-413-C, Box 355065, Seattle, Washington 98195-5065, USA)

  • Yazhou Sun

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Daniela I. Drautz

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Pascal Bouffard

    (Roche Diagnostics Corporation, Indianapolis, Indiana 46250-0414, USA)

  • Donna M. Muzny

    (The Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Jeffrey G. Reid

    (The Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Lynne V. Nazareth

    (The Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Qingyu Wang

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Richard Burhans

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Cathy Riemer

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Nicola E. Wittekindt

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Priya Moorjani

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Elizabeth A. Tindall

    (Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, C25 Lowy Cancer Research Centre University of New South Wales, High Street, New South Wales 2031, Australia
    University of New South Wales, Randwick, New South Wales 2031, Australia)

  • Charles G. Danko

    (101 Biotechnology Building, Cornell University, Ithaca, New York 14853, USA)

  • Wee Siang Teo

    (Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, C25 Lowy Cancer Research Centre University of New South Wales, High Street, New South Wales 2031, Australia
    University of New South Wales, Randwick, New South Wales 2031, Australia)

  • Anne M. Buboltz

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Zhenhai Zhang

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Qianyi Ma

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Arno Oosthuysen

    (PO Box 1899, Tsumeb, Namibia)

  • Abraham W. Steenkamp

    (PO Box 180, Arnos, Namibia)

  • Hermann Oostuisen

    (PO Box 1077, Grootfontein, Namibia)

  • Philippus Venter

    (University of Limpopo, Turfloop Campus, P/Bag X1106, 0727 Sovenga, South Africa)

  • John Gajewski

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Yu Zhang

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • B. Franklin Pugh

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Kateryna D. Makova

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Anton Nekrutenko

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Elaine R. Mardis

    (Washington University in St Louis, School of Medicine, The Genome Center, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA)

  • Nick Patterson

    (Broad Institute of MIT (Massachusetts Institute of Technology) and Harvard University, Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Tom H. Pringle

    (Sperling Foundation, Eugene, Oregon 97405, USA)

  • Francesca Chiaromonte

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • James C. Mullikin

    (National Human Genome Research Institute, National Institutes of Health, 5625 Fishers Lane, Room 5N-01Q, MSC 9400, Rockville, Maryland 20892-9400, USA)

  • Evan E. Eichler

    (University of Washington, and Howard Hughes Medical Institute, Foege S-413-C, Box 355065, Seattle, Washington 98195-5065, USA)

  • Ross C. Hardison

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA)

  • Richard A. Gibbs

    (The Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Timothy T. Harkins

    (Roche Diagnostics Corporation, Indianapolis, Indiana 46250-0414, USA)

  • Vanessa M. Hayes

    (Cancer Genetics Group, Children’s Cancer Institute Australia for Medical Research, C25 Lowy Cancer Research Centre University of New South Wales, High Street, New South Wales 2031, Australia
    University of New South Wales, Randwick, New South Wales 2031, Australia)

Abstract

Southern African genomes The complete genome sequences of an indigenous hunter-gatherer from Namibia's Kalahari Desert and of a Bantu from South Africa are presented in this issue, together with protein-coding regions from three other hunter-gatherer groups from the Kalahari. Analysis of genetic variance in what is probably the oldest known modern human lineage will contribute to understanding human diversity, and facilitate the inclusion of southern Africans in medical genomics research projects. Initial observations from the data include the fact that the Bushmen seem more different from each other, in terms of nucleotide substitutions, than typical Asians and Europeans. More speculatively, variants between these genomes and the existing data sets may point to genetic adaptations for an agricultural lifestyle.

Suggested Citation

  • Stephan C. Schuster & Webb Miller & Aakrosh Ratan & Lynn P. Tomsho & Belinda Giardine & Lindsay R. Kasson & Robert S. Harris & Desiree C. Petersen & Fangqing Zhao & Ji Qi & Can Alkan & Jeffrey M. Kidd, 2010. "Complete Khoisan and Bantu genomes from southern Africa," Nature, Nature, vol. 463(7283), pages 943-947, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7283:d:10.1038_nature08795
    DOI: 10.1038/nature08795
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08795
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08795?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ruha Benjamin, 2015. "The Emperor’s New Genes," The ANNALS of the American Academy of Political and Social Science, , vol. 661(1), pages 130-142, September.
    2. Xiaoru Xie & Liman Huang & Jun (Justin) Li & Hong Zhu, 2020. "Generational Differences in Perceptions of Food Health/Risk and Attitudes toward Organic Food and Game Meat: The Case of the COVID-19 Crisis in China," IJERPH, MDPI, vol. 17(9), pages 1-17, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:463:y:2010:i:7283:d:10.1038_nature08795. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.