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Mical links semaphorins to F-actin disassembly

Author

Listed:
  • Ruei-Jiun Hung

    (The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Umar Yazdani

    (The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Jimok Yoon

    (The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Heng Wu

    (The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Taehong Yang

    (The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Nidhi Gupta

    (The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Zhiyu Huang

    (The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Willem J. H. van Berkel

    (Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA Wageningen, The Netherlands)

  • Jonathan R. Terman

    (The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

Abstract

Mical link for semaphorins and F-actin Semaphorins and plexins relay guidance information to neurons during development and regulate actin dynamics through an unknown mechanism. In recent studies, a family of oxidoreductase enzymes called Mical were found to associate with plexins and mediate axon guidance. Hung et al. demonstrate that in Drosophila, Mical is an F-actin-binding protein that links plexins and semaphorins to the actin cytoskeleton. Changing the levels of Mical in vivo result in reorganization of the actin cytoskeleton, indicating that Mical is required for maintaining the normal size and organization of F-actin bundles. Thus, plexins on the cell surface modulate the actin cytoskeleton via the Mical oxidoreductase.

Suggested Citation

  • Ruei-Jiun Hung & Umar Yazdani & Jimok Yoon & Heng Wu & Taehong Yang & Nidhi Gupta & Zhiyu Huang & Willem J. H. van Berkel & Jonathan R. Terman, 2010. "Mical links semaphorins to F-actin disassembly," Nature, Nature, vol. 463(7282), pages 823-827, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7282:d:10.1038_nature08724
    DOI: 10.1038/nature08724
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    Cited by:

    1. Leishu Lin & Jiayuan Dong & Shun Xu & Jinman Xiao & Cong Yu & Fengfeng Niu & Zhiyi Wei, 2024. "Autoinhibition and relief mechanisms for MICAL monooxygenases in F-actin disassembly," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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