IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v463y2010i7281d10.1038_nature08717.html
   My bibliography  Save this article

Multiple native states reveal persistent ruggedness of an RNA folding landscape

Author

Listed:
  • Sergey V. Solomatin

    (Department of Biochemistry,)

  • Max Greenfeld

    (Stanford University, Stanford, California 94305, USA)

  • Steven Chu

    (Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    University of California, Berkeley, California 94720, USA
    Present address: United States Department of Energy, Washington DC 20585, USA.)

  • Daniel Herschlag

    (Department of Biochemistry,)

Abstract

Funnel vision: RNA folding and refolding Just as the funnel hypothesis is used to describe protein folding, it has been suggested that the process of RNA folding involves a rugged energy terrain in which the molecule samples different valleys until it finds the single lowest-energy state — the global minimum. In this study, Solomatin et al. report the surprising finding that a group I intron RNA can stably exist in one of several catalytically active native states (representing local minima). These RNA conformations are able to interconvert, which promises interesting new avenues of study to determine how this occurs, and how the different native states vary at the molecular level.

Suggested Citation

  • Sergey V. Solomatin & Max Greenfeld & Steven Chu & Daniel Herschlag, 2010. "Multiple native states reveal persistent ruggedness of an RNA folding landscape," Nature, Nature, vol. 463(7281), pages 681-684, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7281:d:10.1038_nature08717
    DOI: 10.1038/nature08717
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08717
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08717?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wonseok Hwang & Il-Buem Lee & Seok-Cheol Hong & Changbong Hyeon, 2016. "Decoding Single Molecule Time Traces with Dynamic Disorder," PLOS Computational Biology, Public Library of Science, vol. 12(12), pages 1-29, December.
    2. Max Greenfeld & Dmitri S Pavlichin & Hideo Mabuchi & Daniel Herschlag, 2012. "Single Molecule Analysis Research Tool (SMART): An Integrated Approach for Analyzing Single Molecule Data," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-12, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:463:y:2010:i:7281:d:10.1038_nature08717. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.