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DNMT1 maintains progenitor function in self-renewing somatic tissue

Author

Listed:
  • George L. Sen

    (Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA)

  • Jason A. Reuter

    (Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA)

  • Daniel E. Webster

    (Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA)

  • Lilly Zhu

    (Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA)

  • Paul A. Khavari

    (Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA
    Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304, USA)

Abstract

Self-renewal preserved In self-renewing mammalian epithelial tissues, which are the sites of many degenerative disorders and human malignancies, the gene regulatory basis for the progenitor cells that maintain the tissues and suppress cell-cycle exit and differentiation is unclear. Khavari and colleagues now show that the DNA methyltransferase DNMT1 and other regulators of DNA methylation are essential for epidermal progenitor cell function, being required to sustain proliferation and suppress differentiation.

Suggested Citation

  • George L. Sen & Jason A. Reuter & Daniel E. Webster & Lilly Zhu & Paul A. Khavari, 2010. "DNMT1 maintains progenitor function in self-renewing somatic tissue," Nature, Nature, vol. 463(7280), pages 563-567, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08683
    DOI: 10.1038/nature08683
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    Cited by:

    1. Sarah M. Lloyd & Daniel B. Leon & Mari O. Brady & Deborah Rodriguez & Madison P. McReynolds & Junghun Kweon & Amy E. Neely & Laura A. Blumensaadt & Patric J. Ho & Xiaomin Bao, 2022. "CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Peter Bailey & Rachel A. Ridgway & Patrizia Cammareri & Mairi Treanor-Taylor & Ulla-Maja Bailey & Christina Schoenherr & Max Bone & Daniel Schreyer & Karin Purdie & Jason Thomson & William Rickaby & R, 2023. "Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Dae Joong Kim & Swetha Anandh & Jamie L. Null & Piotr Przanowski & Sanchita Bhatnagar & Pankaj Kumar & Sarah E. Shelton & Erin E. Grundy & Katherine B. Chiappinelli & Roger D. Kamm & David A. Barbie &, 2023. "Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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