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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Author

Listed:
  • Gillian L. Dalgliesh

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kyle Furge

    (Laboratory of Computational Biology,)

  • Chris Greenman

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Lina Chen

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Graham Bignell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Adam Butler

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Helen Davies

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sarah Edkins

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Claire Hardy

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Calli Latimer

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Jon Teague

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Jenny Andrews

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Syd Barthorpe

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Dave Beare

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Gemma Buck

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Peter J. Campbell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Simon Forbes

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Mingming Jia

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • David Jones

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Henry Knott

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Chai Yin Kok

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • King Wai Lau

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Catherine Leroy

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Meng-Lay Lin

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • David J. McBride

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Mark Maddison

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Simon Maguire

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kirsten McLay

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Andrew Menzies

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Tatiana Mironenko

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Lee Mulderrig

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Laura Mudie

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sarah O’Meara

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Erin Pleasance

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Arjunan Rajasingham

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Rebecca Shepherd

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Raffaella Smith

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Lucy Stebbings

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Philip Stephens

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Gurpreet Tang

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Patrick S. Tarpey

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kelly Turrell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Karl J. Dykema

    (Laboratory of Computational Biology,)

  • Sok Kean Khoo

    (Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA)

  • David Petillo

    (Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA)

  • Bill Wondergem

    (Laboratory of Computational Biology,)

  • John Anema

    (Spectrum Health Hospital, Grand Rapids, Michigan 49503, USA)

  • Richard J. Kahnoski

    (Spectrum Health Hospital, Grand Rapids, Michigan 49503, USA)

  • Bin Tean Teh

    (Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    NCCS-VARI Translational Cancer Research Laboratory, National Cancer Centre)

  • Michael R. Stratton

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK)

  • P. Andrew Futreal

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

Abstract

Chromatin modification in renal carcinoma A large survey for somatic mutations in clear cell renal cell carcinomas, the most common form of adult kidney cancer, shows that in addition to the known inactivating mutations in the VHL gene, recurrent mutations occur in the NF2 gene, which encodes a tumour suppressor protein and in genes encoding the chromatin modifying enzymes SETD2, JARID1C and UTX.

Suggested Citation

  • Gillian L. Dalgliesh & Kyle Furge & Chris Greenman & Lina Chen & Graham Bignell & Adam Butler & Helen Davies & Sarah Edkins & Claire Hardy & Calli Latimer & Jon Teague & Jenny Andrews & Syd Barthorpe , 2010. "Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes," Nature, Nature, vol. 463(7279), pages 360-363, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7279:d:10.1038_nature08672
    DOI: 10.1038/nature08672
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    Cited by:

    1. Christopher J Ricketts & W Marston Linehan, 2015. "Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC)," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-10, October.

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