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Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS

Author

Listed:
  • Tracy S. Tran

    (Solomon H. Snyder Department of Neuroscience,
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Maria E. Rubio

    (University of Connecticut, Storrs, Connecticut 06269, USA)

  • Roger L. Clem

    (Solomon H. Snyder Department of Neuroscience,
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Dontais Johnson

    (Solomon H. Snyder Department of Neuroscience,
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Lauren Case

    (Graduate Program in Neurosciences, Stanford University, Stanford, California 94305, USA)

  • Marc Tessier-Lavigne

    (Graduate Program in Neurosciences, Stanford University, Stanford, California 94305, USA
    Genentech, South San Francisco, California 94080, USA)

  • Richard L. Huganir

    (Solomon H. Snyder Department of Neuroscience,
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • David D. Ginty

    (Solomon H. Snyder Department of Neuroscience,
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Alex L. Kolodkin

    (Solomon H. Snyder Department of Neuroscience,
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

Abstract

Semaphorin signalling Although it is known that different dendritic domains on the same neuron can receive distinct input, the molecular codes underlying these differences have been unknown. Here it is shown that a specific semaphorin signalling pathway, the Sema3F–Npn-2/PlexA4 cascade, that was previously associated with axonal guidance, is involved in the control of dendritic spine development and synapse formation in different dendritic arbours.

Suggested Citation

  • Tracy S. Tran & Maria E. Rubio & Roger L. Clem & Dontais Johnson & Lauren Case & Marc Tessier-Lavigne & Richard L. Huganir & David D. Ginty & Alex L. Kolodkin, 2009. "Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS," Nature, Nature, vol. 462(7276), pages 1065-1069, December.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7276:d:10.1038_nature08628
    DOI: 10.1038/nature08628
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    Cited by:

    1. Jing Hao & Xiangzi Han & Haidong Huang & Xingjiang Yu & Jiankang Fang & Jianjun Zhao & Richard A. Prayson & Shideng Bao & Jennifer S. Yu, 2023. "Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Liang Wang & Ziyun Yang & Fudo Satoshi & Xavier Prasanna & Ziyi Yan & Helena Vihinen & Yaxing Chen & Yue Zhao & Xiumei He & Qian Bu & Hongchun Li & Ying Zhao & Linhong Jiang & Feng Qin & Yanping Dai &, 2024. "Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition," Nature Communications, Nature, vol. 15(1), pages 1-30, December.

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