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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

Author

Listed:
  • Richard C. Grandison

    (Institute of Healthy Ageing, University College London, Gower St, London WC1E 6BT, UK)

  • Matthew D. W. Piper

    (Institute of Healthy Ageing, University College London, Gower St, London WC1E 6BT, UK)

  • Linda Partridge

    (Institute of Healthy Ageing, University College London, Gower St, London WC1E 6BT, UK)

Abstract

A diet for life In a number of organisms, dietary restriction has been shown to extend lifespan at the expense of reduced fecundity. An example of competition for limited resources, the thinking generally goes, as nutrients are reallocated from reproduction to somatic maintenance. Grandison et al. now demonstrate that, in Drosophila, dietary restriction does not induce reallocation, because different amino acids limit lifespan and fecundity. They find that fecundity in long-life flies can be rescued by the addition of methionine alone. Long lifespan and high fecundity can thus occur simultaneously, without dietary restriction itself, by adjustment of the ratio of amino acids in the diet. These findings imply that humans might be able to enjoy the benefits of reduced food intake, without the downsides, by adjustment of dietary nutrients.

Suggested Citation

  • Richard C. Grandison & Matthew D. W. Piper & Linda Partridge, 2009. "Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila," Nature, Nature, vol. 462(7276), pages 1061-1064, December.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7276:d:10.1038_nature08619
    DOI: 10.1038/nature08619
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    Cited by:

    1. Grace Y. Liu & Patrick Jouandin & Raymond E. Bahng & Norbert Perrimon & David M. Sabatini, 2024. "An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ziwei Dai & Weiyan Zheng & Jason W. Locasale, 2022. "Amino acid variability, tradeoffs and optimality in human diet," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Tatyana Y Fedina & Tsung-Han Kuo & Klaus Dreisewerd & Herman A Dierick & Joanne Y Yew & Scott D Pletcher, 2012. "Dietary Effects on Cuticular Hydrocarbons and Sexual Attractiveness in Drosophila," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-11, December.
    4. Noha Sharafeldin & Martha L. Slattery & Qi Liu & Conrado Franco-Villalobos & Bette J. Caan & John D. Potter & Yutaka Yasui, 2017. "Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival," IJERPH, MDPI, vol. 14(10), pages 1-15, September.
    5. Dominic Waithe & Peter Rennert & Gabriel Brostow & Matthew D W Piper, 2015. "QuantiFly: Robust Trainable Software for Automated Drosophila Egg Counting," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-16, May.
    6. Jin-Hyuck Jeong & Jun-Seok Han & Youngae Jung & Seung-Min Lee & So-Hyun Park & Mooncheol Park & Min-Gi Shin & Nami Kim & Mi Sun Kang & Seokho Kim & Kwang-Pyo Lee & Ki-Sun Kwon & Chun-A. Kim & Yong Ryo, 2023. "A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    7. Hina Kosakamoto & Fumiaki Obata & Junpei Kuraishi & Hide Aikawa & Rina Okada & Joshua N. Johnstone & Taro Onuma & Matthew D. W. Piper & Masayuki Miura, 2023. "Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    8. Shengjie Fan & Yingxuan Yan & Ying Xia & Zhenyu Zhou & Lingling Luo & Mengnan Zhu & Yongli Han & Deqiang Yao & Lijun Zhang & Minglv Fang & Lina Peng & Jing Yu & Ying Liu & Xiaoyan Gao & Huida Guan & H, 2023. "Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    9. Cristal M. Hill & Diana C. Albarado & Lucia G. Coco & Redin A. Spann & Md Shahjalal Khan & Emily Qualls-Creekmore & David H. Burk & Susan J. Burke & J. Jason Collier & Sangho Yu & David H. McDougal & , 2022. "FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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